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. 2019 Oct 17;10(11):793. doi: 10.1038/s41419-019-2016-0

Fig. 6. Ras-ERK pathway is required for TIMP3 to regulate EMT, migration, and invasion in oral cancer.

Fig. 6

a The protein expression of EMT-related signaling pathway in oral stable cells. β-actin was used as loading control. b The protein expression of EMT-related signaling pathway in TIMP3 stable cells after transfection of scrambled siRNA or TIMP3 siRNA. β-actin was used as loading control. c EMT-related protein expression after treatment of PD98059 for 48 h. β-actin was used as loading control. d Migration and invasion abilities after treatment of PD98059 for 48 h. *p < 0.05 compared with DMSO. e EMT-related protein expression after transfection of TIMP3 siRNA for 24 h and treatment of PD98059 for another 24 h. β-actin was used as loading control. f Migration and invasion abilities after transfection of TIMP3 siRNA for 24 h and treatment of PD98059 for another 24 h. *p < 0.05 compared to treatment with TIMP3 siRNA and DMSO