Fig. 1.

Hyper-long telomere mice are leaner than normal mice. a Scheme showing generation of mice with hyper-long telomeres. eGFP ES cells are cultured in 2i medium until passage 16 and they are microinjected into morulae to obtain 100% contributing chimaeras. b Representative images showing 100% eGFP ES cell contribution in different organs and tissues. c, d Longitudinal follow up of weight in the indicated cohorts. Hyper-long telomere mice show a significant reduction in body weight from 40 weeks onwards (c) and this body size reduction is maintained until the last timepoint measured (c, d). Error bars represent standard error. t-test was used for statistical analysis. The number of mice is indicated in each case. *p < 0.05. **p < 0.01. Source data are provided as a Source Data file