Fig. 3.

Hyper-long telomere mice show less metabolic aging. a–h Pentra quantification of different serum metabolites at 50, 75, and 100 weeks-old. Metabolites were measured in serum obtained from blood extracts using ABX Pentra, a quantification of creatinine levels, b quantification of total bilirubin levels, c quantification of albumin levels, d quantification of urea levels, e quantification of HDL (high density lipoprotein) levels, f quantification of LDL (low density lipoprotein) levels, g quantification of ALT (alanine aminotransferase) levels and h quantification of cholesterol levels. i–k Glucose tolerance test (GTT). GTT was performed in hyper-long telomere mice and age-matched controls at 50 (i), 75 (j) and 100 (k) weeks of age by intraperitoneal glucose injection after 16 h fasting. l–n Insulin tolerance test (ITT). ITT was performed in hyper-long telomere mice and age-matched controls at 50 (l), 75 (m) and 100 (n) weeks of age by intraperitoneal insulin injection. Error bars represent standard error. t-test was used for statistical analysis. The number of mice is indicated in each case. *p < 0.05. **p < 0.01. ***p < 0.001. Source data are provided as a Source Data file