Fig. 4.

Hyper-long telomere mice live longer and have less spontaneous cancer. a Survival proportions of 100% hyper-long chimeric mice compared to control mice from the same background. Hyper-long telomere mice show a 12.75% increase in median lifespan and an 8.4% increase in maximum lifespan. b Quantification of spontaneous tumor incidence in hyper-long telomere mice and controls. Hyper-long telomere mice show a decrease in almost 20% in tumor incidence compared to control mice from the same background. Error bars represent standard error. Mantel–Cox test was used for statistical analysis in survival curves and Chi-square test for spontaneous tumor incidence. The number of mice is indicated in each case. *p < 0.05. **p < 0.01. ***p < 0.001. Source data are provided as a Source Data file