Fig. 9.

Improved mitochondrial function in mice with hyper-long telomeres. a–c. Relative mtDNA content was calculated by the comparative Ct method of the mitochondrial genes Cox1 (a), Cytb1 (b) and Nd1 (c) compared to the nuclear gene H19 in WAT of 100–110 weeks old hyper-long telomere mice and age-matched controls. d–k. mRNA levels from WAT of the OXPHOS genes Cytochrome C (d), ATP synthase (e), Cytochrome C subunit 6 (f) and Cytochrome C subunit 5a (g) as well as mitochondrial regulators PGC-1a (h) and PGC-1b (i) and critical targets, such as ERRa (j) and PPARa (k). Error bars represent standard error. t-test was used for statistical analysis. The number of mice is indicated in each case. *p < 0.05. **p < 0.01. Source data are provided as a Source Data file