Table 2.
Tumor-to-organ ratios of in BALB/C nu/nu mice bearing SK-RC-52 OV xenografts.
[111In]In-DOTA-HE3-ZCAIX:2 | [99mTc]Tc(CO)3-HE3-ZCAIX:2 | [111In]In-DTPA-G250(Fab’)2 | [111In]In-DTPA-G250(Fab’)2 | |
---|---|---|---|---|
4 h | 4 h | 4 h | 24 h | |
Blood | 63 ± 11a | 23 ± 2d,e | 2.1 ± 0.2b | 67 ± 12 |
Lung | 30 ± 3a | 16 ± 2d,e | 2.7 ± 0.4b | 7 ± 1c |
Liver | 33 ± 2a | 8 ± 2d,e | 0.7 ± 0.3b | 0.6 ± 0.2c |
Spleen | 37 ± 3a | 24 ± 6d,e | 0.7 ± 0.2b | 0.6 ± 0.2c |
Stomach | 36 ± 4a | 22 ± 6d,e | 4.4 ± 0.6b | 6 ± 3c |
Duodenum | 31 ± 8 | 19 ± 6d,e | 2.4 ± 1.2b | 3 ± 2c |
Kidney | 0.038 ± 0.008 | 0.04 ± 0.01d | 0.029 ± 0.005 | 0.03 ± 0.01 |
Muscle | 102 ± 20a | 62 ± 6d,e | 7.9 ± 0.7b | 11 ± 1c |
Bone | 47 ± 8a | 28 ± 3d,e | 3.0 ± 0.5b | 4 ± 1c |
Results are presented as %ID/g (the mean values and standard deviation for four mice).
aSignificant difference (p < 0.05) between [111In]In-DOTA-ZCAIX:2 and [99mTc]Tc(CO)3-HE3-ZCAIX:2;
bSignificant difference (p < 0.05) between [111In]In-DOTA-ZCAIX:2 and [111In]In-G250(Fab’)2 (4 h);
cSignificant difference (p < 0.05) between [111In]In-DOTA-ZCAIX:2 and [111In]In-G250(Fab’)2 (24 h);
dSignificant difference (p < 0.05) between [99mTc]Tc(CO)3-HE3-ZCAIX:2 and [111In]In-G250(Fab’)2 (4 h);
eSignificant difference (p < 0.05) between [99mTc]Tc(CO)3-HE3-ZCAIX:2 and [111In]In-G250(Fab’)2 (4 h).