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. 2019 Oct 17;9:14910. doi: 10.1038/s41598-019-51410-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SC79 rescued myoblast from SM-induced inhibition of C2C12 myogenesis. C2C12 myoblasts were incubated under SM in either the presence or absence of 10 μM SC79 for 24 h, and then were induced to differentiate under 1 g for 48 h. (A) Cells were lysed and subjected to western blotting. (B) Quantitative RT-PCR was performed to analyze the relative levels of MHC, IGF2, and FST. Mouse GAPDH was used to normalize gene expression (n = 6). **P < 0.01 versus undifferentiated control; ^##P < 0.01 versus differentiated control without pre-SM; ^§§P < 0.01 versus differentiated control with pre-SM. Abbreviations: simulated microgravity (SM); differentiation (Diff); myosin heavy chain (MHC); insulin-like growth factor 2 (IGF2); follistatin (FST); simulated microgravity for 24 h before the induction of differentiation (Pre-SM). Data are expressed as mean ± SD, with Mann-Whitney U test performed as indicated.