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. 2019 Oct 17;10(11):790. doi: 10.1038/s41419-019-2019-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Different patterns of γH2AFX localization. MPI substages as zygotene (Z), pachytene (P), or diplotene (D) were assessed by IF-staining of SCP3 and centromeres (red). Scale bar, 10 μm. a Zygotene oocyte with a cloud of γH2AFX-staining over the nucleus. b Mid pachytene oocyte without γH2AFX signals. c Pachytene oocyte with multiple γH2AFX foci along SC axes. d Pachytene oocyte with a γH2AFX-domain over unsynapsed SCs. e Diplotene oocyte without γH2AFX signals. f. Diplotene oocyte with multiple γH2AFX foci. g Diplotene oocyte with two γH2AFX-domains. B The total number of TRA98-positive oocytes counted in microspread ovarian cells. C The percentage of oocytes at meiotic substages. Different capital letters indicate significant differences among the percentages of pachytene or diplotene oocytes at P < 0.01 by ANOVA. D The percentage of oocytes at the pachytene (bottom, darker color) or diplotene (top, lighter color) stage with distinct γH2AFX-staining patterns. Data are shown as mean ± SEM (n ≧ 3). *P < 0.05, statistical significance by t-test