TABLE 1.

Proteins modulated during acid-adaptation after osmoadaptation. Proteins were determined by using a database composed of proteome of P. freudenreichii CIRM-BIA 129 (downloaded from NCBI.nlm.nih.gov 2018).

Accession	Description	YEL+NaCl+ pH = 5/YEL+NaC ratiol
Energy production and conversion
emb|CDP49838.1|	Sulfite reductase [ferredoxin]	0.53
emb|CDP49142.1|	L-lactate permease	0.49
Amino acid transport and metabolism
emb|CDP49535.1|	Cysteine synthase 2	0.49
Replication, recombination and repair
emb|CDP49216.1|	Putative endonuclease III	0.61
Inorganic ion transport and metabolism
emb|CDP49684.1|	ABC-type transport systems, periplasmic component	0.58
emb|CDP48302.1|	Heavy metal transport/detoxification protein	0.54
Secondary metabolites biosynthesis, transport, and catabolism
emb|CDP49310.1|	Dioxygenase	0.64
Function unknown
emb|CDP49347.1|	Uridine phosphorylase	0.52

Ratio were calculated using the XIC methods and indicate induction (ratio > 1.5) or repression (ratio > 0.66) by the acid adaptation.