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. 2019 Oct 11;13:446. doi: 10.3389/fncel.2019.00446

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Copyright © 2019 Sims and Meares.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A subset of ER stress-induced JAK1-dependent signaling is insensitive to kinase inhibition of JAK1. (A) Astrocytes were pretreated with JAK1/2 kinase inhibitor AZD1480 (1 μM) for 1 h before 0.5 h treatment with oncostatin M (OSM). Protein lysates were collected and analyzed by immunoblot. (B) Astrocytes were pretreated with AZD1480 for 1 h and then treated with thaps for 4 h. Gene expression was analyzed by RT-qPCR. Data are represented as means ± standard deviation. N = 3. ^∗p < 0.05.