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. 2019 Oct 11;10:1186. doi: 10.3389/fphar.2019.01186

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Copyright © 2019 Balkrishna, Sakat, Joshi, Joshi, Sharma, Ranjan, Bhattacharya and Varshney

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological analysis of SBKT treatment on TPA-induced ear psoriasis in mice. Histopathological analysis of mice ear tissue was performed following fixation and hematoxylin and eosin staining. Low-magnification images were obtained at 100×, and the higher-magnification image was obtained at 400×. (A) Normal control: represents normal epidermis (Ep), dermis (De), sebaceous gland (Sg), cartilage (CT). (B) Vehicle control (acetone) treated ear: represents normal epidermis (Ep), dermis (De), sebaceous gland (Sg), cartilage (CT). (C) TPA-CON: represents hyperkeratosis (Hk) and hyperplastic epidermis (Ep), presence of inflammatory cells (In) in the dermis region. (D) TPA and DEXA (0.2 mg/ear) treated ear: reduced hyperplastic epidermis (Ep), absence of inflammatory cells in the dermis region. (E) TPA and SBKT (100 mg/kg; p.o. and 20 μl; T.A.) treated ear: reduced hyperkeratosis (Hk) and hyperplastic epidermis (Ep), reduced presence of inflammatory cells (In) in the dermis region. (F) TPA and SBKT (200 mg/kg; p.o. and 20 μl; T.A.) treated ear: reduced hyperkeratosis (Hk) and hyperplastic epidermis (Ep). The scale represents 100 µm (n = 8 animals).