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. 2019 Oct 1;13:438. doi: 10.3389/fncel.2019.00438

FIGURE 1.

FIGURE 1

Investigation of chronic caffeine exposure on spontaneous glutamatergic and GABAergic in vitro activities in 8 and 12 month-old Wild type and Tau mice. Representative traces of sEPSCs and sIPSCs recorded in CA1 hippocampal pyramidal cells of Wild type water (black), Wild type caffeine-treated (gray), Tau water (blue), and Tau caffeine-treated (light blue) mice are depicted on the left of the cumulative probability histograms [8 month-old sEPSCs: (A,B); 12 month-old sEPSCs: (C,D); 8 month-old sIPSCs: (E,F); 12 month-old sIPSCs: (G,H)]. Comparison between cumulative probability distributions was made using the Kolmogorov–Smirnov test (∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001); bar graphs represent mean ± standard error. n = 8 cells, 8 slices, from 5, 8 month-old Wild type water mice vs. n = 8 cells, 8 slices, from 5, 8 month-old Wild type caffeine-treated mice; n = 8 cells, 8 slices, from 5, 8 month-old Wild type water mice vs. n = 9 cells, 9 slices, from 5, 8 month-old Tau water mice; n = 9 cells, 9 slices, from 5, 8 month-old Tau water mice vs. n = 9 cells, 9 slices, from 5, 8 month-old Tau caffeine-treated mice; n = 8 cells, 8 slices, from 5, 8 month-old Wild type caffeine-treated mice vs. n = 9 cells, 9 slices, from 5, 8 month-old Tau caffeine-treated mice; n = 8 cells, 8 slices, from 5, 12 month-old Wild type water mice vs. n = 8 cells, 8 slices, from 5, 12 month-old Wild type caffeine-treated mice; n = 8 cells, 8 slices, from 5, 12 month-old Wild type water mice vs. n = 7 cells, 7 slices, from 4, 12 month-old Tau water mice; n = 7 cells, 7 slices, from 4, 12 month-old Tau water mice vs. n = 9 cells, 9 slices, from 5, 12 month-old Tau caffeine-treated mice; n = 8 cells, 8 slices, from 5, 12 month-old Wild type caffeine-treated mice vs. n = 9 cells, 9 slices, from 5, 12 month-old Tau caffeine-treated mice.