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. 2019 Oct 4;10:1262. doi: 10.3389/fphys.2019.01262

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Copyright © 2019 Kunzelmann, Centeio, Wanitchakool, Cabrita, Benedetto, Saha, Hoque and Schreiber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Defective ion transport in colon of Tmem16a^fl/fl1VilCre mice. (A,C) Original recordings for CCH (100 μM) and IBMX/Fsk (100 μM/2 μM) activated short circuit currents in WT (Tmem16a^fl/fl) and KO (Tmem16a^fl/fl1VilCre) colon, after subtraction of baseline currents measured before stimulation. Transport was assessed in proximal and distal colon. (B,D) Scatter blot summarizing individual experiments. Activation of I_sc by CCH and IBMX/Fsk were significantly attenuated in intestine of KO mice, when compared to WT littermates. Mean ± SEM. Number of animals 5–7. ^#indicates significant difference (unpaired t-test).