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. 2019 Oct 4;10:1262. doi: 10.3389/fphys.2019.01262

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Copyright © 2019 Kunzelmann, Centeio, Wanitchakool, Cabrita, Benedetto, Saha, Hoque and Schreiber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of CO₂ and bicarbonate on ion transport in large intestine. (A,C) Original recordings for CCH (100 μM) and IBMX/Fsk (100 μM/2 μM) activated short circuit currents, after subtraction of baseline currents measured before stimulation. Transport was assessed in proximal and distal colon in the presence of absence of 5%CO₂/25 mM bicarbonate. (B,D) Scatter blot summarizing individual experiments. Activation of I_sc by CCH and IBMX/Fsk was significantly attenuated in the absence of CO₂/bicarbonate. Mean ± SEM. Number of animals 5–7. ^#indicates significant difference (unpaired t-test).