Table 4.
Features differentiating CVID from THI before recovery
| Clinical features | THI before recovery | CVID |
|---|---|---|
| Infections | ++ | ++++ |
| Allergy | ++ | – |
| Autoimmunity | – | ++ |
| Bronchiectasis | +/– | ++ |
| Chronic sinus disease | + | +++ |
| Inflammatory disorders | – | ++ |
| Sarcoid‐like disorders | – | ++ |
| Family history | + | ++ |
| Laboratory features | ||
| IgG | Recovers | Persistently decreased |
| IgA and/or IgM | Recovers | Persistently decreased |
| IgG subclasses | If decreased, recovers | Persistently decreased |
| Vaccine responses | Impaired in some patients | May be impaired |
| Memory B cells | If impaired, recovers | Impaired |
| Isohaemagglutinins | Present | May be absent |
| Tests for autoimmunity | – | ++ |
| Histology | ? | Abnormal* |
| Genetic abnormalities | – | ++ |
*
Abnormal histology includes absent plasma cells, granulomatous disorder, nodular regenerative hyperplasia of the liver and nodular lymphoid hyperplasia of the gut.
CVID = common variable immunodeficiency disorder; THI = transient hypogammabulinaemia of infancy; Ig = immunoglobulin.