Table 2.
Patient data on patients with available lung histology, ordered by clinical phenotype, namely infections‐only (OI) 37, 38, malignancy (MAL) or lymphoproliferation
| Number | Age at CVID diagnosis | Time CVID and death | Time: CVID to ILD symptoms | Age at death | Type of lung sample | CVID phenotype | Granulomata in other sites |
|---|---|---|---|---|---|---|---|
| 1 | 6 | 0 | –2 | n.a. | Bx | IO | No |
| 2 | 8 | 0 | –2 | n.a. | Lobectomy | IO | No |
| 3 | 10 | 7 | 3 | 17 | PM | IO | No |
| 4 | 25 | 10 | 11 | 35 | Bx | IO | No |
| 5 | 32 | 11 | 0 | 43 | Bx | MAL (LI to NHL) | No |
| 6 | 50 | 0 | 3 | n.a. | Bx | MAL (MALToma) | No |
| 7 | 61 | 17 | –11 | 78 | Bx | MAL (MALToma to DLCL) | No |
| 8 | 54 | 0 | 1 | 60 | Bx | MAL (LI to NHL) | No |
| 9 | 48 | 12 | 8 | 60 | Bx | MAL (MALToma to NHL) | No |
| 10 | 36 | 9 | 4 | 45 | PM | MAL (LI to NHL) | No |
| 11 | 27 | 19 | 6 | 46 | Bx | CYT and LP | No |
| 12 | 22 | 24 | 17 | 46 | PM | LP | Brain, lymph node |
| 13 | 27 | 27 | 21 | 54 | PM | CYT and LP | Skin, gut |
| 14 | 62 | 6 | 0 | 68 | Bx | LP | No |
| 15 | 38 | 14 | –4 | 52 | Bx | LP | Lymph nodes |
| 16 | 36 | 0 | 0 | n.a. | Bx | LP | No |
| 17 | 26 | 0 | –8 | n.a. | Bx | LP | No |
| 18 | 28 | 8 | 6 | 36 | Bx | LP | Liver, bone marrow |
| 19 | 14 | 0 | –1 | n.a. | Bx | LP | Lymph nodes |
| 20 | 39 | 0 | 1 | n.a. | Bx | LP | Lymph nodes |
| 21 | 55 | 0 | –4 | n.a. | Bx | LP | No |
| 22 | 54 | 0 | 0 | n.a. | Bx | CYT and LP | Liver |
| 23 | 35 | 40 | 25 | 75 | Bx | LP | No |
| 24 | 45 | 21 | 20 | 66 | Bx | LP | Liver, spleen, lymph nodes |
| 25 | 20 | 0 | –1 | n.a. | Bx | LP | Lymph nodes |
| 26 | 34 | 0 | 5 | n.a. | Bx | LP | Lymph nodes |
| 27 | 60 | 0 | –1 | n.a. | Bx | LP | No |
| 28 | 64 | 0 | 0 | n.a. | Bx | LP | No |
| 29 | 30 | 0 | –14 | n.a. | Bx | LP | No |
IO = infections only common variable immunodeficiency disorder (CVID) phenotype; MAL – lymphoid malignancy; LP = lymphoproliferative CVID phenotype; CTY = cytopenia CVID phenotype; Bx = biopsy; PM = post‐mortem findings; LI = lymphocytic infiltration; NHL = non‐Hodgkin lymphoma; DLCL = diffuse large cell lymphoma; n.a. = not applicable. Pretreatment with corticosteroids; included in final histological patterns.