Figure 2.
CTHRC1 protein expression levels are elevated in PRAD tumors, and this is associated with tumor recurrence and poor clinical outcome. Scale bar, 100 µm; original magnification, ×400. (A) DFS rates were compared between the CTHRC1high and CTHRC1low groups. Analysis of DFS was accomplished using The Cancer Genome Atlas cohort. (B) Increases in CTHRC1 protein expression in PRAD generated from the validation cohort, followed by immunohistochemistry straining for CTHRC1. Typical images of CTHRC1 staining in tumors without recurrence (n=80) or with recurrence (n=42). (C) CTHRC1 protein expression levels were markedly increased in prostate cancer LNCaP and PC-3 cell lines compared with human prostate normal cells RwPE-2. CTHRC1, collagen triple helix repeat containing 1; HR, hazard ratio; PRAD, prostate adenocarcinoma; DFS, disease free survival.