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. 2019 Sep 20;20(5):4634–4644. doi: 10.3892/mmr.2019.10693

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Copyright: © Patankar et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Figure 1. — Time-course development from native and KRAS or BRAF mutated colon cancer cells in 3D cultures. The evolution of clusters from day 7 to 10, using Hoechst (nuclear) staining. Control Caco-2 cells formed cysts, while focal cell piling, occasionally accompanied by apoptosis (Day 9), is present in Caco-2-KRAS cells, and Caco-2-BRAF cells show formation of solid structures. Scale bar represents 20 µm. 3D, 3-dimensional.