Table I.

Review of reported 3D growth patterns and anoikis resistance in native Caco-2 cells, Caco-2 cells transfected with KRAS or BRAF mutations (present study), and intestinal carcinoma cell lines with inherent KRAS or BRAF mutation.

Cell line	KRAS or BRAF mutation	3D growth pattern	Anoikis resistance	(Refs.)
Caco-2	None	Polarized cyst	NS	(32,52)
Caco-2	None	Polarized cyst	+	Patankar M (Present study)
Caco2-KRAS	KRAS, G12V	Solid	NS	(32)
HCT 116	KRAS, G13D	Solid	NS	(15,53–55)
		NS	+
SW 408	KRAS, G12V	Solid	NS	(52,54)
Caco2-KRAS	KRAS, G12V	Solid	+	Patankar M (present study)
Caco2-BRAF	BRAF, V600E	Solid	NS	(32)
HT29	BRAF, V600E	Solid	NS	(15,53,54)
		NS	+
DLD-1	BRAF, V600E	Solid	NS	(53,54)
Caco2-BRAF	BRAF, V600E	Solid	+	Patankar M (present study)

3-D, 3 dimensional; NS, not studied; +, studied.