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. 2019 Oct 11;11:277. doi: 10.3389/fnagi.2019.00277

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Copyright © 2019 Egimendia, Minassian, Diedenhofen, Wiedermann, Ramos-Cabrer and Hoehn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DMN connectivity. Top left: mean z-score value of all interactions between DMN regions is represented. All other diagrams: cross-correlation of pairs of ROIs of the DMN is represented. An increasingly strong interaction is seen in month 8.5 comparing to 2.5 in GP-Hp, Cg-Hyth, Hyth-Hp, Hp-Th and Hyth-Th correlations. There is also a decrease of correlation from month 8.5 to month 12.5 in Hyth-GP, Cg-Hyth, PrL-Hp and Hyth-Th. An inverse U-shape curve is typically seen. Error bars indicate SD. *p < 0.05, **p < 0.01 and ***p < 0.001.