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. 2019 Sep 27;6:93. doi: 10.3389/fmolb.2019.00093

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Copyright © 2019 Kandzia, Ostermeir and Zacharias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of crystal structures (cartoon representation) of yeast Hsp90 with bound AMPNPP (A, pdb2cg9), a Hsp90-Cdc37-Cdk4 complex bound with ATP (B, pdb5fwl), a mitochondrial homolog with bound ADP (C, pdb2o1v), a bacterial homolog with bound ADP (D, pdb2ioq) and an “open” ADP-bound structure based on sFRET data (E, Hellenkamp et al., 2016). In (A) the location of the N-, M-, and C-domains is indicated and color-coded for one monomer, the second monomer is in gray. In case of (B–E) one monomer is colored from light (N) to dark (C), while the other is in gray for visibility. The colors range from blueish (closed conformation) to reddish (open conformation).