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. 2019 Sep 25;6:82. doi: 10.3389/fmolb.2019.00082

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Copyright © 2019 Dehghani, Rosenblatt, Li, Rakhade and Amato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lowest limits of detection for SNVs and Indels. The lowest limit of detection of OCAv1 for identifying SNVs and indels, with expected allele frequencies of ~2.5–50%, were evaluated using the AOHL member 1 to member 6 ladders and were sequenced. (A) Indicates the detection rates of the assay for SNVs and Indels with expected allele frequencies of ~5–30% (hotspot and non-hotspot variants); and, (B) shows the detection rate of the assay for variants listed in the hotspot bed file.