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. 2019 Sep 24;13:67. doi: 10.3389/fncom.2019.00067

FIGURE 6.

FIGURE 6

The sequence replay in PFC network induced by non-specific spontaneous noisy input. (A) Under the noisy input to the trained PFC network, the sequence emerges randomly among the PY cell populations with a varying replay length and initiating neurons (noise level = 0.052 nA2). All the neurons are indexed the same as in Figure 3A. (B) For the untrained PFC network, the firing activity is random and no sequence replay emerges. All the neurons are indexed the same as in Figure 3A. (C) The MIs of sequence replay in the trained network for different noisy input levels. For low noisy inputs, sequence replay cannot emerge. The MI value reaches the maximum for intermediate noisy input levels. For high noise level, the sequence replay in the trained network do not differ significantly from that in the untrained one (∗ significant at p < 0.05, ∗∗∗ significant at p < 0.001, rank sum test). (D) The MIs of sequence replay in the trained network for different AMPA synapse losses. Even though the MIs are low, they still differ significantly from those in the untrained PFC network (∗ significant at p < 0.05, ∗∗ significant at p < 0.01, and ∗∗∗ significant at p < 0.001, rank sum test).