Table 1B.
Association of CIC subtypes with clinicopathological characteristics.
| LiT | LiM | HeCIC | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics | N (%) | No#n (%) | Yes#n (%) | χ2 | P | No#n (%) | Yes#n (%) | χ2 | P | No#n (%) | Yes#n (%) | χ2 | P |
| Total | 148 | 142 (95.9) | 6 (4.1) | 126 (85.1) | 22 (14.9) | 38 (25.7) | 110 (74.3) | ||||||
| Age (years) | 0.466 | 0.495 | 1.762 | 0.184 | 1.504 | 0.220 | |||||||
| ≤ 60 | 105 (70.9) | 100 (95.2) | 5 (4.8) | 92 (87.6) | 13 (12.4) | 24 (22.9) | 81 (77.1) | ||||||
| >60 | 43 (29.1) | 42 (97.7.4) | 1 (2.3) | 34 (79.1) | 9 (20.9) | 14 (32.6) | 29 (67.4) | ||||||
| Histological grade | 3.949 | 0.139 | 0.176 | 0.916 | 3.104 | 0.212 | |||||||
| 1 | 16 (10.8) | 16 (100.0) | 0 (0.0) | 14 (87.5) | 2 (12.5) | 7 (43.8) | 9 (56.2) | ||||||
| 2 | 127 (85.8) | 122 (96.1) | 5 (3.9) | 108 (85.0) | 19 (15.0) | 30 (23.6) | 97 (76.4) | ||||||
| 3 | 5 (3.4) | 4 (80.0) | 1 (20.0) | 4 (80) | 1 (20) | 1 (20.0) | 4 (80.0) | ||||||
| TNM stage | 1.394 | 0.498 | 3.232 | 0.199 | 0.499 | 0.779 | |||||||
| I | 13 (8.8) | 13 (100.0) | 0 (0.0) | 12 (92.3) | 1 (7.7) | 3 (23.1) | 10 (76.9) | ||||||
| II | 91 (61.5) | 86 (94.5) | 5 (5.5) | 80 (87.9) | 11 (12.1) | 22 (24.2) | 69 (75.8) | ||||||
| III | 44 (29.7) | 43 (97.7) | 1 (2.3) | 34 (77.3) | 10 (22.7) | 13 (29.5) | 31 (70.5) | ||||||
| Tumor size | 0.7825 | 0.676 | 2.488 | 0.288 | 0.868 | 0.648 | |||||||
| <2 cm | 35 (23.6) | 34 (97.1) | 1 (2.9) | 32 (91.4) | 3 (8.6) | 11 (31.4) | 24 (68.6) | ||||||
| 2–5 cm | 102 (68.9) | 97 (95.1) | 5 (4.9) | 86 (84.3) | 16 (15.7) | 24 (23.5) | 78 (76.5) | ||||||
| > 5 cm | 11 (7.4) | 11 (100.0) | 0 (0.0) | 8 (72.7) | 3 (27.3) | 3 (27.3) | 8 (72.7) | ||||||
| Lymph node metastasis | 1.609 | 0.447 | 2.261 | 0.323 | 1.293 | 0.524 | |||||||
| 0 | 62 (41.9) | 58 (93.5) | 4 (6.5) | 53 (85.5) | 9 (14.5) | 13 (21.0) | 49 (79.0) | ||||||
| 1–2 | 36 (24.3) | 35 (97.2) | 1 (2.8) | 33 (91.7) | 3 (8.3) | 10 (27.8) | 26 (72.2) | ||||||
| > 3 | 50 (33.8) | 49 (98.0) | 1 (2.0) | 40 (80.0) | 10 (20.0) | 15 (30.0) | 35 (70.0) | ||||||
| ER status | 0.745 | 0.391 | 4.979 | 0.026 | 0.214 | 0.644 | |||||||
| Positive | 98 (66.2) | 95 (96.9) | 3 (3.1) | 88 (89.8) | 10 (10.2) | 24 (24.5) | 74 (75.5) | ||||||
| Negative | 50 (33.8) | 47 (94.0) | 3 (6.0) | 38 (76.0) | 12 (24.0) | 14 (28.0) | 36 (72.0) | ||||||
| PR status | 1.672 | 0.196 | 3.408 | 0.065 | 0.064 | 0.800 | |||||||
| Positive | 87 (58.8) | 85 (97.7) | 2 (2.3) | 78 (89.7) | 9 (10.3) | 23 (26.4) | 64 (73.6) | ||||||
| Negative | 61 (41.2) | 57 (93.4) | 4 (6.6) | 48 (78.7) | 13 (21.3) | 15 (24.6) | 46 (75.4) | ||||||
| Her2 status | 1.865 | 0.172 | 0.270 | 0.603 | 0.323 | 0.570 | |||||||
| Positive | 34 (23.0) | 34 (100.0) | 0 (0.0) | 28 (82.4) | 6 (17.6) | 10 (29.4) | 24 (70.6) | ||||||
| Negative | 114 (77.0) | 108 (94.7) | 6 (5.3) | 98 (86.0) | 16 (14.0) | 28 (24.6) | 86 (75.4) | ||||||
| Subtype | 8.525 | 0.074 | 11.268 | 0.024 | 3.442 | 0.487 | |||||||
| Lum A | 69 (46.6) | 68 (98.6) | 1 (146) | 65 (94.2) | 4 (5.8) | 19 (27.5) | 50 (72.5) | ||||||
| Lum B (Her2+) | 16 (10.8) | 14 (87.5) | 2 (12.5) | 13 (81.3) | 3 (18.7) | 2 (12.5) | 14 (87.5) | ||||||
| Lum B (Her2−) | 19 (12.8) | 19 (100.0) | 0 (0.0) | 15 (78.9) | 4 (21.1) | 4 (21.1) | 15 (78.9) | ||||||
| Her2+/HR− | 15 (10.1) | 15 (100.0) | 0 (0.0) | 13 (86.7) | 2 (13.3) | 6 (40.0) | 9 (60.0) | ||||||
| TNBC | 29 (19.6) | 26 (89.7) | 3 (10.3) | 20 (69.0) | 9 (31.0) | 7 (24.1) | 22 (75.9) | ||||||
| EGFR status | 2.316 | 0.128 | 4.215 | 0.040 | 0.096 | 0.757 | |||||||
| Positive | 108 (73) | 102 (94.4) | 6 (5.6) | 88 (81.5) | 20 (18.5) | 27 (25.0) | 81 (75.0) | ||||||
| Negative | 40 (27) | 40 (100.0) | 0 (0.0) | 38 (95.0) | 2 (5.0) | 11 (27.5) | 29 (72.5) | ||||||
| Ki67 status | 9.292 | 0.002 | 1.996 | 0.158 | 3.987 | 0.046 | |||||||
| <14% | 106 (71.6) | 105 (99.1) | 1 (0.9) | 93 (87.7) | 13 (12.3) | 32 (30.2) | 74 (69.8) | ||||||
| ≥14% | 42 (28.4) | 31 (88.1) | 11 (11.9) | 33 (78.6) | 9 (21.4) | 6 (14.3) | 36 (85.7) | ||||||
#
No: 0 CICs/core; Yes, ≥1 CICs/core. Lum: luminal. Bold values represent the statistical difference (p < 0.05).