Table 3.
Multivariate Cox-regression analysis of overall survival with CICs as a variable.
| Variables | oCIC | TiT | MiT | TiM | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | HR | P | n | HR | P | n | HR | P | n | HR | P | |
| CICs | 0.423 (0.227–0.785) | 0.006 | 0.529 (0.288–0.973) | 0.04 | 2.608 (1.344–5.063) | 0.05 | 0.524 (0.286–0.962) | 0.037 | ||||
| ≤ 15 | 42 | 49 | 122* | 49* | ||||||||
| >15 | 106 | 99 | 26# | 99# | ||||||||
| Age | 2.038 (1.055–3.937) | 0.034 | – | – | 2.173 (1.138–4.147) | 0.019 | – | – | ||||
| ≤ 60 | 105 | 105 | 105 | 105 | ||||||||
| >60 | 43 | 43 | 43 | 43 | ||||||||
| TNM stage | 2.119 (1.189–3.774) | 0.011 | 1.692 (1.001–2.860) | 0.049 | 2.117 (1.192–3.759) | 0.01 | – | – | ||||
| I | 13 | 13 | 13 | 13 | ||||||||
| II | 91 | 91 | 91 | 91 | ||||||||
| III | 44 | 44 | 44 | 44 | ||||||||
| Subtype | 1.307 (1.084–1.576) | 0.005 | 1.350 (1.121–1.625) | 0.002 | 1.310 (1.081–1.588) | 0.006 | 1.354 (1.128–1.626) | 0.001 | ||||
| Lum A | 69 | 69 | 69 | 69 | ||||||||
| Lum B (Her2+) | 16 | 16 | 16 | 16 | ||||||||
| Lum B (Her2−) | 19 | 19 | 19 | 19 | ||||||||
| Her2+/HR− | 15 | 15 | 15 | 15 | ||||||||
| TNBC | 29 | 29 | 29 | 29 | ||||||||
*
Number of samples negative in MiT or TiM;
#
number of samples positive in MiT or TiM; Lum, luminal. Bold values represent the statistical difference (p < 0.05).