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. 2019 Oct 11;12:239. doi: 10.3389/fnmol.2019.00239

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Copyright © 2019 Karami, Eriksdotter, Kadir, Almkvist, Nordberg and Darreh-Shori.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between ChAT_F activity or the Cholinergic index and the ADAS-Cog test results following 9–12 months of galantamine treatment. Panel (A) illustrates correlations between Cognition assessed by ADAS-Cog and the ChAT_F activity in CSF at 12 months. Panel (B) shows the corresponding correlation with Cholinergic index in CSF. It should be noted that a high ADAS-Cog score reflects a worse cognitive performance. Thus, the graphs illustrate positive correlation between the CSF cholinergic biomarkers and cognition. Open orange squares = the Placebo-Galantamine group. Dark squares = the Galantamine group. ChAT = choline acetyltransferase. CSF ChAT_F activity = the overall functional ChAT activity expressed in pmol/min/μg ChAT protein in the samples. CSF Cholinergic Index = ratio of ChAT_F activity to AChE_F in CSF.