Table 2.
Correlations between the in vivo AChE activity (k3), cognitive measures, the CSF ChATF activity and the Cholinergic Index after 12 months.
| CSF ChATF activity | CSF Cholinergic index | ||||
|---|---|---|---|---|---|
| in vivo AChE activity in the brain (k3) | r (n = 5) | p < 0.05 | r (n = 5) | p < 0.05 | |
| Cortical regions | L | 0.92 | 0.023 | 0.98 | 0.0009 |
| R | 0.90 | 0.040 | 0.95 | 0.009 | |
| Overall brain regions | L | 0.92 | 0.022 | 0.96 | 0.007 |
| R | 0.83 | 0.090 | 0.84 | 0.084 | |
| Average cortical regions | 0.93 | 0.020 | 0.99 | 0.0003 | |
| Average overall brain regions | 0.94 | 0.015 | 0.97 | 0.004 | |
| Whole brain | 0.96 | 0.0044 | 0.98 | 0.0012 | |
| Cognitive tests | r (n = 8) | p < 0.05 | r (n = 8) | p < 0.05 | |
| MMSE Score | 0.7 | 0.03 | 0.6 | 0.1 | |
| ADAS-Cog | −0.81 | 0.013 | −0.83 | 0.008 | |
| Neuropsychology tests: Attention Domain | 0.56 | 0.15 | 0.40 | 0.34 | |
| Memory Domain | 0.50 | 0.22 | 0.77 | 0.022 | |
| Visuospatial Domain | 0.85 | 0.0052 | 0.72 | 0.040 | |
k3 = the binding constant calculated as described (Kadir et al., 2008). The k3 rate constants for the in vivo AChE activity are shown in Figure 2. All r-values are correlation coefficient. Some of the correlations are illustrated graphically in Figure 2 and Figure 6. PET, Positron emission tomography; CSF, Cerebrospinal fluid; R and L the right and left brain hemispheres. A large K3 means high in vivo AChE activity. CSF ChATF activity refers to choline acetyltransferase activity divided by its protein concentration; Cholinergic Index, refers to ratio of CSF ChATF activity/CSF AChEF activity; MMSE Score, the mini-mental state exam; ADAS-Cog, Alzheimer’s Disease Assessment Scale.