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. 2019 Oct 11;10:2423. doi: 10.3389/fimmu.2019.02423

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Copyright © 2019 Abu-Raya, Giles, Kollmann and Sadarangani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fractional absolute anti-PT IgG levels by time of vaccination against pertussis in pregnancy achieved at the different ammonium thiocyanate concentrations. The quantified fractional absolute avidity levels of anti-PT IgG at 0.25 molar (M), 0.5, 1, 1.5, 2, and 3 M of ammonium thiocyanate are classified as low (A), low-medium (B), medium (C), medium-high (D), high (E), and very high (F) avidity anti-PT IgG antibodies, respectively. The horizontal line denotes the cord mean levels in newborns born to unvaccinated women. PT, pertussis toxin; IU/ml, international unit/ml. This figure shows that the earlier Tdap is given in pregnancy the higher fractional absolute levels of low-medium, medium, medium–high, and high avidity anti-PT IgG levels are achieved at birth.