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. 2019 Sep 30;93(20):e00711-19. doi: 10.1128/JVI.00711-19

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Copyright © 2019 American Society for Microbiology.

This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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FIG 3 — ExoN-AA adapts for increased fitness within 10 passages. (A) Replication kinetics of the indicated viruses at an MOI of 0.01 PFU/cell plotted as means ± standard deviations (n = 3). (B) 5-Fluorouracil sensitivity at an MOI of 0.01 PFU/cell. (C) Competitive fitness of individual recombinants relative to that of ExoN-AA. Viruses were competed with a tagged ExoN-AA-reference strain, and relative fitness was normalized to the mean of the ExoN-AA value. Statistical significance of each virus relative to that of ExoN-AA was determined by two-way analysis of variance with Dunnett’s multiple-comparison test (B) or by one-way analysis of variance with multiple comparisons (C). ****, P < 0.0001; ns, not significant. LOD, limit of detection. Data in panels B and C represent means ± standard deviations (n = 6). Boxed values have the same significance.