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. 2019 Sep 30;93(20):e00934-19. doi: 10.1128/JVI.00934-19

FIG 4.

FIG 4

DDMMPP immunization elicits significantly higher CD4 T cell responses, while DDMMM immunization elicits higher CD8 T cell responses. (A) Longitudinal total SHIV-specific IFN-γ+ CD4 T cell response. Geometric means for the group are shown. (B to D) SHIV-specific IFN-γ+, IL-21+, and IL-4+ CD4 T cell responses 1 week after the final immunization. Pie charts depict the relative distributions of the CD4 T cell responses to Gag, Env1, and Env2 peptide pools. (E) Longitudinal total SHIV-specific IFN-γ+ CD8 T cell response. Geometric means for the group are shown. (F to H) SHIV-specific IFN-γ+, IL-21+, and CD107+ CD8 T cell responses 1 week after the final immunization. Pie charts depict the relative distributions of the CD8 T cell responses to Gag, Env1, and Env2 peptide pools. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.