TABLE 1.
Canonical pathways enriched in common expressed genes (Top 10 enrichment).
| Infection models | Canonical pathway | p-value | Mola/molb |
| A549 | Interferon signaling | 3.88e-24 | 15/36 |
| Activation of IRF by cytosolic pattern recognition receptors | 3.52e-13 | 11/64 | |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 7.43e-10 | 11/127 | |
| Antigen presentation pathway | 3.92e-09 | 7/37 | |
| Retinoic acid mediated apoptosis signaling | 2.04e-07 | 7/64 | |
| Role of RIG-I-like receptors in antiviral innate immunity | 3.94e-07 | 6/49 | |
| Communication between innate and adaptive immune cells | 2.18e-06 | 7/112 | |
| Role of JAK1, JAK2, and TYK2 in interferon signaling | 1.66e-05 | 4/28 | |
| Crosstalk between dendritic cells and natural killer cells | 2.72e-05 | 6/106 | |
| Type I diabetes mellitus signaling | 7.59e-05 | 6/121 | |
| 293T | Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F | 1.04e-04 | 3/18 |
| Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F | 2.22e-04 | 3/23 | |
| Airway inflammation in asthma | 2.63e-04 | 2/5 | |
| Hepatic cholestasis | 3.21e-04 | 6/177 | |
| Agranulocyte adhesion and diapedesis | 4.68e-04 | 6/190 | |
| Granulocyte adhesion and diapedesis | 2.41e-3 | 1/179 | |
| Role of cytokines in mediating communication between immune cells | 3.07e-03 | 3/56 | |
| Activation of IRF by cytosolic pattern recognition receptors | 4.47e-03 | 3/64 | |
| T helper cell differentiation | 6.22e-03 | 3/72 | |
| TNFR2 signaling | 9.85e-03 | 2/29 |
IPA was used to determine the top 10 canonical pathways. The p-value was used to rank the significance associated with each pathway. aNumber of molecules differentially expressed in the canonical pathways. bTotal number of molecules in the annotated canonical pathways.