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(A) Time course of corneal anesthesia. The y-axis shows the filament length on a Cochet-Bonnet esthesiometer needed to elicit a blink after single application of topical anesthetics. (B) Durations of Block0.5 (complete), Block3 (deep), and Block<6 (partial) corneal anesthesia following a single topical application of corneal anesthetics. Data are means ± SD (N = 5) and were calculated from the data presented in (A). No animals in the 15 mM PPC or 15 mM QX-314 groups achieved Block0.5.
