Table 3.
The temporal change trend of primary drug resistance rate among newly diagnosed TB cases in Shandong, China, 2004–2018
| Characteristics | Primary drug resistance rate(%) | Changea (%) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2005–2017 | |
| DR-TB (Total) | 24.34 | 17.91 | 19.73 | 17.81 | 19.72 | 13.97 | 30.28 | 19.75 | 17.99 | 17.83 | 17.26 | 18.66 | 19.10 | 19.44 | 21.38 | −12.17 |
| Type | ||||||||||||||||
| MR-TB | 20.07 | 13.48 | 12.66 | 9.58 | 11.49 | 8.48 | 18.35 | 11.59 | 9.47 | 11.25 | 9.44 | 11.97 | 11.44 | 12.37 | 13.35 | −33.48 |
| MDR-TB | 1.32 | 1.01 | 3.35 | 3.29 | 2.84 | 2.74 | 5.50 | 3.23 | 4.40 | 3.59 | 3.22 | 3.14 | 2.96 | 2.78 | 3.73 | 183.71 |
| PDR-TB | 2.96 | 3.42 | 3.72 | 4.94 | 5.39 | 2.74 | 4.59 | 4.56 | 4.11 | 2.99 | 4.49 | 3.55 | 4.70 | 4.17 | 4.30 | 45.20 |
| Age (years) | ||||||||||||||||
| 15–44 | 18.59 | 15.53 | 19.35 | 21.03 | 19.93 | 14.12 | 29.17 | 19.55 | 17.88 | 18.94 | 16.08 | 21.49 | 19.58 | 20.49 | 24.44 | 31.49 |
| 45–64 | 32.47 | 19.31 | 19.92 | 16.10 | 18.69 | 14.39 | 41.18 | 21.99 | 19.34 | 19.64 | 19.93 | 18.35 | 21.67 | 20.00 | 21.10 | −35.01 |
| > 65 | 28.17 | 20.30 | 19.80 | 14.72 | 20.23 | 12.22 | 10.53 | 17.05 | 16.40 | 13.77 | 15.82 | 15.11 | 15.50 | 17.77 | 17.84 | −36.66 |
| Sex | ||||||||||||||||
| Male | 25.91 | 17.49 | 19.21 | 18.37 | 21.11 | 15.95 | 27.84 | 20.95 | 17.91 | 18.47 | 17.95 | 18.08 | 19.93 | 19.76 | 21.60 | −16.62 |
| Female | 20.24 | 19.30 | 21.29 | 16.15 | 15.85 | 8.16 | 50.00 | 13.33 | 18.52 | 13.99 | 14.10 | 21.39 | 14.91 | 17.65 | 20.27 | 0.16 |
| Cavity | ||||||||||||||||
| Yes | 20.83 | 12.00 | 25.27 | 18.29 | 20.73 | 10.38 | 35.29 | 18.53 | 25.39 | 18.59 | 18.34 | 19.73 | 20.70 | 20.40 | 22.13 | 6.24 |
| No | 24.90 | 19.51 | 17.72 | 17.46 | 19.26 | 15.71 | 25.00 | 20.55 | 13.10 | 17.08 | 15.63 | 19.24 | 15.43 | 21.17 | 18.34 | −26.34 |
| Smoking | ||||||||||||||||
| Yes | 21.57 | 13.04 | 15.00 | 15.09 | 19.23 | 18.78 | 19.48 | 16.67 | 21.05 | 26.09 | 20.95 | |||||
| No | 23.08 | 15.63 | 16.67 | 21.23 | 16.67 | 17.24 | 16.11 | 19.18 | 19.37 | 19.12 | 19.43 | −15.79 | ||||
| Drinking | ||||||||||||||||
| Yes | 10.26 | 11.76 | 18.86 | 12.39 | 19.34 | 21.34 | 19.35 | 16.45 | 15.74 | 26.55 | 158.85 | |||||
| No | 25.00 | 19.29 | 16.67 | 19.53 | 17.52 | 17.41 | 15.59 | 19.44 | 19.39 | 20.16 | 19.45 | −22.18 | ||||
| First-line drugs | ||||||||||||||||
| INH | 13.49 | 11.07 | 12.16 | 11.62 | 12.62 | 8.98 | 16.51 | 11.21 | 12.82 | 10.46 | 8.98 | 8.82 | 9.40 | 8.84 | 10.29 | −23.67 |
| RFP | 1.97 | 1.81 | 3.97 | 3.78 | 3.97 | 3.49 | 6.42 | 4.46 | 5.17 | 4.98 | 5.06 | 4.87 | 4.70 | 4.17 | 5.77 | 192.31 |
| EMB | 1.97 | 0.80 | 0.99 | 1.84 | 2.13 | 0.25 | 1.83 | 2.18 | 1.34 | 0.80 | 2.42 | 1.01 | 1.53 | 1.89 | 1.47 | −25.49 |
| SM | 12.17 | 9.46 | 12.41 | 13.36 | 12.91 | 8.73 | 21.10 | 12.73 | 11.48 | 11.35 | 13.12 | 13.79 | 14.61 | 14.52 | 15.27 | 25.47 |
Primary drug resistance rate(%) were calculated as follows: (the quantity of each DR-TB subgroups/ the quantity of corresponding primary TB cases (total) in the same year)*100%, for example, primary drug resistance rate(%) of female TB cases in 2018 = the quantity of female DR-TB cases in 2018/ the quantity of total female primary TB cases in 2018) * 100%
Joinpoint regression of these crude ratios were shown in Table 4
TB Tuberculosis, DR-TB Drug-resistant tuberculosis, MR-TB Mono-resistant tuberculosis, MDR-TB Multi-resistant tuberculosis, PDR-TB Polydrug resistant tuberculosis, EMB Ethambutol, INH Isoniazid, RFP Rifampin, SM Streptomycin
aThe % changes were calculated as follows: (incidence in 2018-incidence in 2005)/incidence in 2005