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. 2019 Oct 17;7:264. doi: 10.1186/s40425-019-0737-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Stratification analysis in subgroups of age, sex, cancer type, TMB status and drug class in the validation cohort. Breast cancer, colorectal cancer, esophagogastric cancer, glioma, head and neck cancer, renal cell carcinoma and cancer of unknown primary were combined into ‘other cancers’ as the TET1-MUT cases or deaths were insufficient for hazard ratio calculation in each single cancer type. ‘Monotherapy’ indicated monotherapy of CTLA-4, PD-1 or PD-L1 antibody; ‘combination therapy’ indicated combination therapy of CTLA-4 with PD-(L)1 antibodies