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. 2019 Oct 17;7:264. doi: 10.1186/s40425-019-0737-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — TET1-MUT was associated with enhanced tumor immunogenicity and activated anti-tumor immunity. a. Comparison of tumor mutational burden between the TET1-MUT and TET1-WT tumors in the Samstein’s cohort (left panel) and the TCGA cohort (right panel). b. Comparison of neoantigen load between the TET1-MUT and TET1-WT tumors in the TCGA cohort. c. Heatmap depicting the log2-transformed fold change in the mean tumor-infiltrating leukocytes MCP-counter scores of the TET1-MUT tumors compared to TET1-WT tumors across different cancer types. d. Heatmap depicting the log2-transformed fold change in the mean immune signature ssGSEA scores of the TET1-MUT tumors compared to TET1-WT tumors across different cancer types. e. Heatmap depicting the mean differences in immune-related gene mRNA expressions between TET1-MUT and TET1-WT tumors across different cancer types. The x-axis of the heatmap indicated different cancer types and the y-axis indicated tumor-infiltrating leukocytes, immune signatures, or gene names. Each square represented the fold change or difference of each indicated tumor-infiltrating leukocyte, immune signature, or immune-related gene between TET1-MUT and TET1-WT tumors in each cancer type. Red indicated up-regulation while blue indicated down-regulation