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. 2019 Oct 17;12:138. doi: 10.1186/s12920-019-0587-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Laboratory evidence suggesting a duplication. a Next-generation sequencingNGS data showing an apparent duplication of exons 5–10 of BRCA2. Exons at normal dosage align to two alleles on the y-axis, whereas in duplications they align to three alleles. b Microarray-based comparative genomic hybridization data clearly demonstrate that the duplication also includes the first half of exon 11. Microarray probe clusters at normal dosage center at zero on the y-axis, whereas duplications center to approximately 0.4–0.5