Fig. 1.

Resveratrol (RES) exhibits anti-proliferation activity and induces apoptosis in human ovarian carcinoma cells SKOV3 and A2780. a Chemical structure of resveratrol. b Dose-dependent killing of SKOV3 and A2780 cells by RES was determined by MTT assay. The cell viability was examined after 48 h incubation. c Colony formation ability of SKOV3 and A2780 cells after treated with RES (25 μM or 50 μM). Photographs of crystal violet-stained colonies are shown. d Fluorescence images of live/dead SKOV3 and A2780 cells after treated with different doses of RES. Cell viability was detected using LIVE/DEAD™ Viability/Cytotoxicity Kit. Live and dead cells were stained as green and red. Annexin V and PI staining by flow cytometric to analyze the percentages of apoptosis cells in SKOV3 cells (e) and A2780 cells (f) after treatment with different doses of RES