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. 2019 Sep 3;26(11):1323–1332. doi: 10.1093/jamia/ocz104

Table 1.

Components of the comprehensive medication review of the PRIMA-eDS tool

Component Data source used
Check of the indications of current medications Evidence-Based Medicine Guidelines and evidence summary collection12
Measurement results (laboratory, anthropometric) with alerts Evidence-Based Medicine Guidelines12 and consensus of the EbMeDS clinical editorial team13
Recommendations about amending current medications based on best available evidence EbMeDS evidence-based rules14
Systematic reviews on drugs commonly prescribed to older people15
EU(7)-PIM list16
Dosage adjustment in renal malfunction RENBASE database17
Potentially harmful drug-drug interactions INXBASE database18
Contraindications Pharmacological literature and summary of medicinal product characteristics by the European Medicines Agency19
Dose warnings Pharmacological literature and product summaries approved by regulatory authorities
Possible adverse drug reactions RISKBASE database20

EbMeDS: Evidence-Based Medicine electronic Decision Support; EU(7)-PIM: European Union (7)-potentially inappropriate medications; PRIMA-eDS: Polypharmacy in chronic diseases: Reduction of Inappropriate Medication and Adverse drug events in older populations by electronic Decision Support.