. 2019 Sep 3;26(11):1323–1332. doi: 10.1093/jamia/ocz104

Table 1.

Components of the comprehensive medication review of the PRIMA-eDS tool

Component	Data source used
Check of the indications of current medications	Evidence-Based Medicine Guidelines and evidence summary collection¹²
Measurement results (laboratory, anthropometric) with alerts	Evidence-Based Medicine Guidelines¹² and consensus of the EbMeDS clinical editorial team¹³
Recommendations about amending current medications based on best available evidence	EbMeDS evidence-based rules¹⁴
	Systematic reviews on drugs commonly prescribed to older people¹⁵
	EU(7)-PIM list¹⁶
Dosage adjustment in renal malfunction	RENBASE database¹⁷
Potentially harmful drug-drug interactions	INXBASE database¹⁸
Contraindications	Pharmacological literature and summary of medicinal product characteristics by the European Medicines Agency¹⁹
Dose warnings	Pharmacological literature and product summaries approved by regulatory authorities
Possible adverse drug reactions	RISKBASE database²⁰

EbMeDS: Evidence-Based Medicine electronic Decision Support; EU(7)-PIM: European Union (7)-potentially inappropriate medications; PRIMA-eDS: Polypharmacy in chronic diseases: Reduction of Inappropriate Medication and Adverse drug events in older populations by electronic Decision Support.