Supplementary Table I.
List of proteins identified exclusively in the FF from PCOS group in comparison to OD group.
| SwissProt ID | Name | Class | Molecular Function | Cellular compartment | Number of Patients |
|---|---|---|---|---|---|
| Q17R60 | Interphotoreceptor matrix proteoglycan 1 | Glicoproteína de matriz extracelular (PC00102); receptor (PC00100) | receptor activity(GO:0004872) | extracellular region(GO:0005576) | 3 |
| Q8WXI7 | Mucin-16 | NA | NA | NA | 3 |
| PNA1NA42 | Complement C3 | NA | cysteine-type endopeptidase inhibitor activity(GO:0003824) | #N/D | 2 |
| P02765 | Alpha-2-HS-glycoprotein | Inibidor de cisteína protease (PC00095); Glicoproteína de matriz extracelular (PC00191) | peptidase inhibitor activity(GO:0003824) | extracellular space(GO:0005576) | 2 |
| P02774 | Vitamin D-binding protein | NA | NA | NA | 2 |
| Q15020 | Squamous cell carcinoma antigen recognized by T-cells 3 | NA | NA | NA | 2 |
| A6NDX4 | Putative transmembrane protein | NA | NA | #N/D | 1 |
| O14526 | FCH domain only protein 1 | Proteína de citoesqueleto da família das actinas (PC00085); proteína reguladora de trafficking de membrana (PC00041) | NA | NA | 1 |
| O14578 | Citron Rho-interacting kinase | non-receptor serine/threonine protein kinase(PC00220) | protein kinase activity(GO:0003824) | NA | 1 |
| O15020 | Spectrin beta chain, non-erythrocytic 2 | non-motor actin binding protein(PC00085) | actin binding(GO:0005488);structural constituent of cytoskeleton(GO:0005515) | intracellular(GO:0044464) | 1 |
| O15357 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | phosphatase(PC00121) | NA | NA | 1 |
| O75445 | Usherin | extracellular matrix linker protein(PC00102);receptor(PC00101) | receptor activity(GO:0004872) | extracellular matrix(GO:0031012);extracellular region(GO:0005576) | 1 |
| O75691 | Small subunit processome component 20 homolog | NA | NA | intracellular(GO:0044464);nucleolus(GO:0005622);ribonucleoprotein complex(GO:0043226) | 1 |
| P00739 | Haptoglobin-related protein | annexin(PC00060);calmodulin(PC00050);peptide hormone(PC00131);protease inhibitor(PC00061);receptor(PC00207);serine protease(PC00179) | NA | NA | 1 |
| P01008 | Antithrombin-III | serine protease inhibitor(PC00095) | serine-type endopeptidase inhibitor activity(GO:0003824);serine-type peptidase activity(GO:0016787) | extracellular space(GO:0005576) | 1 |
| P01019 | Angiotensinogen | serine protease inhibitor(PC00095) | serine-type endopeptidase inhibitor activity(GO:0003824);serine-type peptidase activity(GO:0016787) | extracellular space(GO:0005576) | 1 |
| P02538 | Keratin, type II cytoskeletal 6A | intermediate filament(PC00085);structural protein(PC00129) | structural constituent of cytoskeleton(GO:0005198) | intermediate filament cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| P02671 | Fibrinogen alpha chain | signaling molecule(PC00207) | receptor binding(GO:0005488) | extracellular region(GO:0005576) | 1 |
| P02675 | Fibrinogen beta chain | signaling molecule(PC00207) | receptor binding(GO:0005488) | extracellular region(GO:0005576) | 1 |
| P02679 | Fibrinogen gamma chain | NA | NA | NA | 1 |
| P02790 | Hemopexin | transfer/carrier protein(PC00219) | NA | extracellular matrix(GO:0031012) | 1 |
| P04259 | Keratin, type II cytoskeletal 6B | intermediate filament(PC00085);structural protein(PC00129) | structural constituent of cytoskeleton(GO:0005198) | intermediate filament cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| P08574 | Cytochrome c1, heme protein, mitochondrial | NA | NA | cytoplasm(GO:0044464);mitochondrion(GO:0005622) | |
| P08603 | Complement factor H | NA | NA | NA | 1 |
| P09529 | Inhibin beta B chain | growth factor(PC00207) | transforming growth factor beta receptor binding(GO:0005488) | extracellular space(GO:0005576) | 1 |
| P13645 | Keratin, type I cytoskeletal 10 | intermediate filament(PC00085);structural protein(PC00129) | structural constituent of cytoskeleton(GO:0005198) | intermediate filament cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| P19827 | Inter-alpha-trypsin inhibitor heavy chain H1 | serine protease inhibitor(PC00095) | protein binding(GO:0005488);serine-type endopeptidase inhibitor activity(GO:0005515) | NA | 1 |
| P20742 | Pregnancy zone protein | complement component(PC00090);cytokine(PC00078);serine protease inhibitor(PC00207) | cytokine activity(GO:0005488);serine-type endopeptidase inhibitor activity(GO:0005515) | NA | 1 |
| P27169 | Serum paraoxonase/arylesterase 1 | NA | hydrolase activity, acting on ester bonds(GO:0003824) | NA | 1 |
| P33991 | DNA replication licensing factor MCM4 | DNA helicase(PC00171);hydrolase(PC00009) | DNA helicase activity(GO:0003824);hydrolase activity(GO:0004386);nucleic acid binding(GO:0003678) | NA | 1 |
| P35908 | Keratin, type II cytoskeletal 2 epidermal | intermediate filament(PC00085);structural protein(PC00129) | structural constituent of cytoskeleton(GO:0005198) | intermediate filament cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| P48668 | Keratin, type II cytoskeletal 6C | intermediate filament(PC00085);structural protein(PC00129) | structural constituent of cytoskeleton(GO:0005198) | intermediate filament cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| P49454 | Centromere protein F | NA | NA | NA | 1 |
| P49589 | Cysteine--tRNA ligase, cytoplasmic | RNA binding protein(PC00171);aminoacyl-tRNA synthetase(PC00031) | aminoacyl-tRNA ligase activity(GO:0003824) | cytosol(GO:0044464) | 1 |
| P49842 | Serine/threonine-protein kinase 19 | NA | NA | NA | 1 |
| P78312 | Protein FAM193A | NA | NA | NA | 1 |
| P98170 | E3 ubiquitin-protein ligase XIAP | protease inhibitor(PC00095) | cysteine-type endopeptidase inhibitor activity(GO:0003824);ubiquitin-protein ligase activity(GO:0016787) | cytoplasm(GO:0044464);microtubule(GO:0005622);nucleus(GO:0005737) | 1 |
| Q12873 | Chromodomain-helicase-DNA-binding protein 3 | DNA helicase(PC00171) | NA | NA | 1 |
| Q13129 | Zinc finger protein Rlf | nuclease(PC00171);transcription factor(PC00170) | nuclease activity(GO:0003824);sequence-specific DNA binding transcription factor activity(GO:0016787) | NA | 1 |
| Q15813 | Tubulin-specific chaperone E | chaperone(PC00072) | NA | NA | 1 |
| Q3KP22 | Uncharacterized protein C11orf85 | NA | NA | NA | 1 |
| Q53GS7 | Nucleoporin GLE1 | nucleic acid binding(PC00171);transfer/carrier protein(PC00219) | nucleic acid binding(GO:0005488) | NA | 1 |
| Q63HN8 | E3 ubiquitin-protein ligase RNF213 | NA | NA | NA | 1 |
| Q6YP21 | Kynurenine--oxoglutarate transaminase 3 | transaminase(PC00220) | transaminase activity(GO:0003824) | NA | 1 |
| Q70CQ2 | Ubiquitin carboxyl-terminal hydrolase 34 | NA | NA | NA | 1 |
| Q7Z6M1 | Rab9 effector protein with kelch motifs | NA | NA | NA | 1 |
| Q86YQ8 | Copine-8 | membrane traffic protein(PC00150) | NA | NA | 1 |
| Q8IWT3 | Cullin-9 | NA | NA | NA | 1 |
| Q8IY50 | Putative thiamine transporter SLC35F3 | NA | NA | NA | 1 |
| Q8N9W7 | Putative transmembrane protein FLJ36131 | NA | #N/D | #N/D | 1 |
| Q8NHM4 | Putative trypsin-6 | serine protease(PC00121) | serine-type peptidase activity(GO:0003824) | extracellular space(GO:0005576) | 1 |
| Q8TDI0 | Chromodomain-helicase-DNA-binding protein 5 | DNA helicase(PC00171) | NA | NA | 1 |
| Q8TF01 | Arginine/serine-rich protein PNISR | NA | NA | NA | 1 |
| Q92665 | 28S ribosomal protein S31, mitochondrial | NA | NA | NA | 1 |
| Q9H1H9 | Kinesin-like protein KIF13A | microtubule binding motor protein(PC00085) | microtubule motor activity(GO:0003824) | cytoskeleton(GO:0043226);intracellular(GO:0005856);protein complex(GO:0044464) | 1 |
| Q9NQ66 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | calcium-binding protein(PC00060);guanyl-nucleotide exchange factor(PC00095);phospholipase(PC00022);signaling molecule(PC00113) | calcium ion binding(GO:0005488);guanyl-nucleotide exchange factor activity(GO:0005509);phospholipase activity(GO:0003824);receptor binding(GO:0030234);small GTPase regulator activity(GO:0005085) | NA | 1 |
| Q9NTG1 | Polycystic kidney disease and receptor for egg jelly-related protein | G-protein modulator(PC00095);ion channel(PC00022);membrane-bound signaling molecule(PC00227) | Cation channel activity(GO:0005215) | NA | 1 |
| Q9P212 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | calcium-binding protein(PC00060);guanyl-nucleotide exchange factor(PC00095);phospholipase(PC00022);signaling molecule(PC00113) | calcium ion binding(GO:0005488);guanyl-nucleotide exchange factor activity(GO:0005509);phospholipase activity(GO:0003824);receptor binding(GO:0030234);small GTPase regulator activity(GO:0005085) | NA | 1 |
| Q9P225 | Dynein heavy chain 2, axonemal | hydrolase(PC00121);microtubule binding motor protein(PC00085) | microtubule motor activity(GO:0003824);structural constituent of cytoskeleton(GO:0016787) | intracellular(GO:0044464);microtubule(GO:0005622) | 1 |
| Q9P2N5 | RNA-binding protein 27 | RNA binding protein(PC00171) | RNA binding(GO:0005488) | NA | 1 |
| Q9UKA4 | RNA-binding protein 27 | kinase modulator(PC00095) | protein binding(GO:0005488) | cytoplasm(GO:0044464) | 1 |