Supplementary Table II.
List of proteins identified exclusively in the FF from OD group in comparison to PCOS group.
| SwissProt ID | Name | Class | Molecular Function | Cellular compartment | Number of Patients |
|---|---|---|---|---|---|
| P43686 | 26S protease regulatory subunit 6B | hydrolase(PC00121) | protein binding(GO:0005488) | cytosol(GO:0044464);nucleus(GO:0005622);protein complex(GO:0005737) | 2 |
| Q8IWI9 | MAX gene-associated protein | nucleic acid binding(PC00171);transcription factor(PC00218) | sequence-specific DNA binding transcription factor activity(GO:0005488) | NA | 2 |
| Q9Y4A5 | Transformation/transcription domain-associated protein | non-receptor serine/threonine protein kinase(PC00220);nucleotide kinase(PC00137) | kinase activity(GO:0003824) | NA | 2 |
| A0AUZ9 | KAT8 regulatory NSL complex subunit 1-like protein | NA | NA | NA | 1 |
| A5PLK6 | Regulator of G-protein signaling protein-like | G-protein modulator(PC00095) | GTPase activity(GO:0003824);enzyme activator activity(GO:0016787);pyrophosphatase activity(GO:0003924) | cytoplasm(GO:0044464);plasma membrane(GO:0005622) | 1 |
| A6NJZ7 | RIMS-binding protein 3C | NA | NA | NA | 1 |
| A6NNM3 | RIMS-binding protein 3B | NA | NA | NA | 1 |
| O00268 | Transcription initiation factor TFIID subunit 4 | NA | NA | NA | 1 |
| O14641 | Segment polarity protein dishevelled homolog DVL-2 | enzyme modulator(PC00095);signaling molecule(PC00207) | receptor binding(GO:0005488) | cytosol(GO:0044464) | 1 |
| O14948 | Transcription factor EC | basic helix-loop-helix transcription factor(PC00218) | NA | NA | 1 |
| O15294 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | glycosyltransferase(PC00220) | transferase activity, transferring glycosyl groups(GO:0003824) | NA | 1 |
| O43187 | Interleukin-1 receptor-associated kinase-like 2 | NA | protein kinase activity(GO:0003824) | cytoplasm(GO:0044464);nucleus(GO:0005622) | 1 |
| O43451 | Maltase-glucoamylase, intestinal | glucosidase(PC00121) | glucosidase activity(GO:0003824) | NA | 1 |
| O60229 | Kalirin | guanyl-nucleotide exchange factor(PC00095);signaling molecule(PC00022) | guanyl-nucleotide exchange factor activity(GO:0003824);receptor binding(GO:0030234);small GTPase regulator activity(GO:0005085) | NA | 1 |
| O60318 | Germinal-center associated nuclear protein | ATP synthase(PC00227);hydrolase(PC00068) | cation transmembrane transporter activity(GO:0005215);hydrogen ion transmembrane transporter activity(GO:0022857);hydrolase activity(GO:0008324) | NA | 1 |
| O60494 | Cubilin | apolipoprotein(PC00219);cell adhesion molecule(PC00052);enzyme modulator(PC00069);extracellular matrix protein(PC00095);membrane-bound signaling molecule(PC00102);metalloprotease(PC00207);oxidase(PC00152);serine protease(PC00121);transporter(PC00190) | enzyme regulator activity(GO:0003824);lipid transporter activity(GO:0030234);metallopeptidase activity(GO:0005215);oxidoreductase activity(GO:0005319);receptor activity(GO:0016787);serine-type peptidase activity(GO:0008233);transmembrane transporter activity(GO:0008237) | extracellular matrix(GO:0031012);extracellular region(GO:0005576) | 1 |
| O75094 | Slit homolog 3 protein | NA | NA | NA | 1 |
| O75901 | Ras association domain-containing protein 9 | membrane traffic protein(PC00150) | NA | NA | 1 |
| O94813 | Slit homolog 2 protein | NA | NA | NA | 1 |
| O95206 | Protocadherin-8 | cadherin(PC00069) | calcium ion binding(GO:0005488) | NA | 1 |
| O95490 | Latrophilin-2 | G-protein coupled receptor(PC00197);antibacterial response protein(PC00021) | receptor activity(GO:0004872) | NA | 1 |
| O95613 | Pericentrin | chromatin/chromatin-binding protein(PC00171);hydrolase(PC00009);kinase modulator(PC00077) | chromatin binding(GO:0005488);hydrolase activity(GO:0003682);kinase regulator activity(GO:0003824);nucleic acid binding(GO:0016787);protein binding(GO:0016740) | NA | 1 |
| O95661 | GTP-binding protein Di-Ras3 | small GTPase(PC00095) | GTPase activity(GO:0003824);protein binding(GO:0016787) | NA | 1 |
| O95835 | Serine/threonine-protein kinase LATS1 | annexin(PC00060);calmodulin(PC00050);non-receptor serine/threonine protein kinase(PC00131);transfer/carrier protein(PC00061) | protein kinase activity(GO:0003824) | intracellular(GO:0044464) | 1 |
| O95947 | T-box transcription factor TBX6 | nucleic acid binding(PC00171);transcription factor(PC00218) | sequence-specific DNA binding transcription factor activity(GO:0005488) | NA | 1 |
| P01857 | Ig gamma-1 chain C region | NA | antigen binding(GO:0005488);receptor binding(GO:0003823) | extracellular space(GO:0005576);immunoglobulin complex(GO:0005615);plasma membrane(GO:0032991) | 1 |
| P06396 | Gelsolin | non-motor actin binding protein(PC00085) | actin binding(GO:0005488);structural constituent of cytoskeleton(GO:0005515) | actin cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| P07333 | Macrophage colony-stimulating factor 1 receptor | NA | NA | NA | 1 |
| P0C7U3 | Probable palmitoyltransferase ZDHHC11B | NA | NA | NA | 1 |
| P13761 | HLA class II histocompatibility antigen, DRB1-7 beta chain | #N/D | #N/D | #N/D | 1 |
| P35527 | Keratin, type I cytoskeletal 9 | intermediate filament(PC00085);structural protein(PC00129) | structural constituent of cytoskeleton(GO:0005198) | intermediate filament cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| P42345 | Serine/threonine-protein kinase mT | non-receptor serine/threonine protein kinase(PC00220);nucleotide kinase(PC00137) | kinase activity(GO:0003824) | NA | 1 |
| P46013 | Antigen KI-67 | NA | NA | NA | 1 |
| P49750 | YLP motif-containing protein 1 | nucleic acid binding(PC00171) | nucleic acid binding(GO:0005488) | NA | 1 |
| P49792 | E3 SUM | G-protein modulator(PC00095) | protein binding(GO:0005488);small GTPase regulator activity(GO:0005515) | NA | 1 |
| P51805 | Plexin-A3 | signaling molecule(PC00207);tyrosine protein kinase receptor(PC00197) | NA | NA | 1 |
| P98161 | Polycystin-1 | G-protein modulator(PC00095);ion channel(PC00022);membrane-bound signaling molecule(PC00227) | cation channel activity(GO:0005215) | NA | 1 |
| Q04637 | Eukaryotic translation initiation factor 4 gamma 1 | translation initiation factor(PC00171) | translation initiation factor activity(GO:0045182) | NA | 1 |
| Q08170 | Serine/arginine-rich splicing factor 4 | NA | NA | NA | 1 |
| Q08AE8 | Protein spire homolog 1 | actin family cytoskeletal protein(PC00085) | structural constituent of cytoskeleton(GO:0005198) | intracellular(GO:0044464) | 1 |
| Q13402 | Unconventional myosin-VIIa | G-protein modulator(PC00095);actin binding motor protein(PC00022);cell junction protein(PC00085) | enzyme regulator activity(GO:0003824);motor activity(GO:0030234);protein binding(GO:0016787);structural constituent of cytoskeleton(GO:0016462) | actin cytoskeleton(GO:0043226);intracellular(GO:0005856);plasma membrane(GO:0015629) | 1 |
| Q13563 | Polycystin-2 | G-protein modulator(PC00095);ion channel(PC00022);membrane-bound signaling molecule(PC00227) | cation channel activity(GO:0005215) | NA | 1 |
| Q14643 | Inositol 1,4,5-trisphosphate receptor type 1 | ligand-gated ion channel(PC00227) | ligand-gated ion channel activity(GO:0005215);receptor activity(GO:0022857) | NA | 1 |
| Q14980 | Nuclear mitotic apparatus protein 1 | NA | NA | NA | 1 |
| Q15149 | Plectin | non-motor actin binding protein(PC00085) | actin binding(GO:0005488);structural constituent of cytoskeleton(GO:0005515) | actin cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| Q15413 | Ryanodine receptor 3 | ligand-gated ion channel(PC00227) | ligand-gated ion channel activity(GO:0005215);receptor activity(GO:0022857) | NA | 1 |
| Q15772 | Striated muscle preferentially expressed protein kinase | G-protein coupled receptor(PC00197);immunoglobulin receptor superfamily(PC00021);immunoglobulin superfamily cell adhesion molecule(PC00090);protein phosphatase(PC00124) | NA | NA | 1 |
| Q16531 | DNA damage-binding protein 1 | damaged DNA-binding protein(PC00171);mRNA polyadenylation factor(PC00009) | damaged DNA binding(GO:0005488) | intracellular(GO:0044464);nucleus(GO:0005622);protein complex(GO:0043226) | 1 |
| Q2LD37 | Uncharacterized protein KIAA1109 | NA | NA | NA | 1 |
| Q3B7T1 | Erythroid differentiation-related factor 1 | NA | NA | NA | 1 |
| Q460N5 | Poly [ADP-ribose] polymerase 14 | nucleic acid binding(PC00171) | nucleic acid binding(GO:0005488) | NA | 1 |
| Q562E7 | WD repeat-containing protein 81 | esterase(PC00121);kinase inhibitor(PC00097);mRNA splicing factor(PC00095) | NA | NA | 1 |
| Q5JSL3 | Dedicator of cytokinesis protein 11 | guanyl-nucleotide exchange factor(PC00095) | guanyl-nucleotide exchange factor activity(GO:0003824);small GTPase regulator activity(GO:0030234) | NA | 1 |
| Q5T5C0 | Syntaxin-binding protein 5 | membrane trafficking regulatory protein(PC00150) | GTPase activity(GO:0003824);enzyme activator activity(GO:0016787);pyrophosphatase activity(GO:0003924) | cytoplasm(GO:0044464);plasma membrane(GO:0005622) | 1 |
| Q5TC82 | Roquin-1 | NA | NA | NA | 1 |
| Q5TZA2 | Rootletin | kinase modulator(PC00095);viral protein(PC00140) | kinase regulator activity(GO:0003824);protein binding(GO:0016740) | NA | 1 |
| Q5UIP0 | Telomere-associated protein RIF1 | NA | NA | NA | 1 |
| Q5VST9 | Obscurin | immunoglobulin receptor superfamily(PC00090);immunoglobulin superfamily cell adhesion molecule(PC00124);protein phosphatase(PC00069) | NA | NA | 1 |
| Q5VT52 | Regulation of nuclear pre-mRNA domain-containing protein 2 | kinase inhibitor(PC00095) | kinase inhibitor activity(GO:0003824);protein binding(GO:0030234) | NA | 1 |
| Q5VUA4 | Zinc finger protein 318 | NA | NA | NA | 1 |
| Q5VYK3 | Proteasome-associated protein ECM29 homolog | kinase modulator(PC00095) | kinase regulator activity(GO:0003824);protein binding(GO:0016740) | NA | 1 |
| Q5VZM2 | Ras-related GTP-binding protein B | small GTPase(PC00095) | GTPase activity(GO:0003824);pyrophosphatase activity(GO:0016787) | cytoplasm(GO:0044464);endosome(GO:0005622);lysosome(GO:0005737);membrane(GO:0043226);protein complex(GO:0005768);vacuole(GO:0005764) | 1 |
| Q66K64 | DDB1- and CUL4-associated factor 15 | NA | NA | NA | 1 |
| Q6P9F0 | Coiled-coil domain-containing protein 62 | #N/D | #N/D | #N/D | 1 |
| Q6ZN55 | Zinc finger protein 574 | KRAB box transcription factor(PC00218) | NA | NA | 1 |
| Q6ZT12 | E3 ubiquitin-protein ligase UBR3 | NA | NA | cytoplasm(GO:0044464);protein complex(GO:0005622) | 1 |
| Q6ZV29 | Patatin-like phospholipase domain-containing protein 7 | esterase(PC00121) | phospholipase activity(GO:0003824) | cytoplasm(GO:0044464);endoplasmic reticulum(GO:0005622) | 1 |
| Q70JA7 | Chondroitin sulfate synthase 3 | glycosyltransferase(PC00220) | transferase activity, transferring glycosyl groups(GO:0003824) | NA | 1 |
| Q7L523 | Ras-related GTP-binding protein A | small GTPase(PC00095) | GTPase activity(GO:0003824);pyrophosphatase activity(GO:0016787) | cytoplasm(GO:0044464);endosome(GO:0005622);lysosome(GO:0005737);membrane(GO:0043226);protein complex(GO:0005768);vacuole(GO:0005764) | 1 |
| Q7Z494 | Nephrocystin-3 | NA | NA | microtubule(GO:0043226) | 1 |
| Q7Z794 | Keratin, type II cytoskeletal 1b | intermediate filament(PC00085);structural protein(PC00129) | structural constituent of cytoskeleton(GO:0005198) | intermediate filament cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |
| Q7Z7G8 | Vacuolar protein sorting-associated protein 13B | NA | NA | NA | 1 |
| Q7Z7M0 | Multiple epidermal growth factor-like domains protein 8 | extracellular matrix linker protein(PC00102);receptor(PC00101);small GTPase(PC00197) | GTPase activity(GO:0003824);receptor activity(GO:0016787) | extracellular matrix(GO:0031012);extracellular region(GO:0005576) | 1 |
| Q86TS7 | Putative UPF0730 protein encoded by LINC00643 | NA | NA | NA | 1 |
| Q8IVE3 | Pleckstrin homology domain-containing family H member 2 | NA | NA | NA | 1 |
| Q8IYF3 | Testis-expressed sequence 11 protein | chaperone(PC00072) | NA | NA | 1 |
| Q8IZD9 | Dedicator of cytokinesis protein 3 | guanyl-nucleotide exchange factor(PC00095) | guanyl-nucleotide exchange factor activity(GO:0003824);small GTPase regulator activity(GO:0030234) | NA | 1 |
| Q8N3S3 | Putative homeodomain transcription factor 2 | homeobox transcription factor(PC00218);nucleic acid binding(PC00116) | sequence-specific DNA binding transcription factor activity(GO:0005488) | NA | 1 |
| Q8N4F7 | RING finger protein 175 | ubiquitin-protein ligase(PC00142) | NA | Golgi apparatus(GO:0043226);cytoplasm(GO:0005794);endoplasmic reticulum(GO:0044464);nuclear outer membrane-endoplasmic reticulum membrane network(GO:0005622) | 1 |
| Q8N4S9 | MARVEL domain-containing protein 2 | tight junction(PC00070);transcription cofactor(PC00214) | sequence-specific DNA binding transcription factor activity(GO:0005488);transcription cofactor activity(GO:0003676) | plasma membrane(GO:0016020) | 1 |
| Q8N554 | Zinc finger protein 276 | NA | NA | NA | 1 |
| Q8N8Z8 | Zinc finger protein 441 | NA | NA | NA | 1 |
| Q8NA56 | Tetratricopeptide repeat protein 29 | guanyl-nucleotide exchange factor(PC00095);transmembrane receptor regulatory/adaptor protein(PC00022) | guanyl-nucleotide exchange factor activity(GO:0003824);small GTPase regulator activity(GO:0030234) | NA | 1 |
| Q8NE71 | ATP-binding cassette sub-family F member 1 | ATP-binding cassette (ABC) transporter(PC00227);hydrolase(PC00003);translation elongation factor(PC00121) | ATPase activity, coupled to transmembrane movement of substances(GO:0003824);translation elongation factor activity(GO:0016787);transmembrane transporter activity(GO:0042626) | NA | 1 |
| Q8NEZ4 | Histone-lysine N-methyltransferase 2C | DNA binding protein(PC00171);methyltransferase(PC00009) | NA | NA | 1 |
| Q8NF91 | Nesprin-1 | non-motor actin binding protein(PC00085) | actin binding(GO:0005488);structural constituent of cytoskeleton(GO:0005515) | intracellular(GO:0044464) | 1 |
| Q8NFC6 | Biorientation of chromosomes in cell division protein 1-like 1 | NA | NA | NA | 1 |
| Q8NG31 | Protein CASC5 | NA | NA | NA | 1 |
| Q8NI35 | InaD-like protein | NA | NA | NA | 1 |
| Q8TER5 | Rho guanine nucleotide exchange factor 40 | guanyl-nucleotide exchange factor(PC00095);signaling molecule(PC00022) | guanyl-nucleotide exchange factor activity(GO:0003824);receptor binding(GO:0030234);small GTPase regulator activity(GO:0005085) | NA | 1 |
| Q8WVC0 | RNA polymerase-associated protein LE | DNA-directed RNA polymerase(PC00171) | NA | intracellular(GO:0044464);nucleus(GO:0005622) | 1 |
| Q8WWG9 | Potassium voltage-gated channel subfamily E member 4 | NA | NA | NA | 1 |
| Q92823 | Neuronal cell adhesion molecule | G-protein coupled receptor(PC00197);immunoglobulin receptor superfamily(PC00021);immunoglobulin superfamily cell adhesion molecule(PC00090);protein phosphatase(PC00124) | NA | NA | 1 |
| Q969F9 | Hermansky-Pudlak syndrome 3 protein | NA | NA | NA | 1 |
| Q969V4 | Tektin-1 | NA | NA | NA | 1 |
| Q96B21 | Transmembrane protein 45B | NA | NA | NA | 1 |
| Q96ID5 | Immunoglobulin superfamily member 21 | immunoglobulin receptor superfamily(PC00090);immunoglobulin superfamily cell adhesion molecule(PC00124);protein phosphatase(PC00069) | NA | NA | 1 |
| Q96MB7 | Putative nuclease HARBI1 | NA | NA | NA | 1 |
| Q96NH3 | Protein broad-minded | NA | NA | NA | 1 |
| Q96PX9 | Pleckstrin homology domain-containing family G member 4B | guanyl-nucleotide exchange factor(PC00095);signaling molecule(PC00022) | guanyl-nucleotide exchange factor activity(GO:0003824);receptor binding(GO:0030234);small GTPase regulator activity(GO:0005085) | NA | 1 |
| Q9BQ52 | Zinc phosphodiesterase ELAC protein 2 | NA | endoribonuclease activity(GO:0003824) | NA | 1 |
| Q9BSC4 | Nucleolar protein 10 | NA | NA | NA | 1 |
| Q9GIY3 | HLA class II histocompatibility antigen, DRB1-14 beta chain | #N/D | #N/D | #N/D | 1 |
| Q9GZQ4 | Neuromedin-U receptor 2 | G-protein coupled receptor(PC00197) | receptor activity(GO:0004872) | NA | 1 |
| Q9H0X9 | Oxysterol-binding protein-related protein 5 | NA | NA | NA | 1 |
| Q9H1A4 | Anaphase-promoting complex subunit 1 | ligase(PC00142) | ligase activity(GO:0003824) | NA | 1 |
| Q9H254 | Spectrin beta chain, non-erythrocytic 4 | non-motor actin binding protein(PC00085) | actin binding(GO:0005488);structural constituent of cytoskeleton(GO:0005515) | intracellular(GO:0044464) | 1 |
| Q9H7M6 | Zinc finger SWIM domain-containing protein 4 | NA | NA | NA | 1 |
| Q9NRL2 | Bromodomain adjacent to zinc finger domain protein 1A | acetyltransferase(PC00220);chromatin/chromatin-binding protein(PC00038) | acetyltransferase activity(GO:0003824);chromatin binding(GO:0016740);nucleic acid binding(GO:0016746) | NA | 1 |
| Q9NZC2 | Bromodomain adjacent to zinc finger domain protein 1A | immunoglobulin receptor superfamily(PC00090) | receptor activity(GO:0004872) | NA | 1 |
| Q9P107 | GEM-interacting protein | NA | NA | NA | 1 |
| Q9P227 | Rho GTPase-activating protein 23 | NA | GTPase activity(GO:0003824);enzyme activator activity(GO:0016787);pyrophosphatase activity(GO:0003924) | NA | 1 |
| Q9UFD9 | RIMS-binding protein 3A | NA | NA | NA | 1 |
| Q9UFH2 | Dynein heavy chain 17, axonemal | hydrolase(PC00121);microtubule binding motor protein(PC00085) | microtubule motor activity(GO:0003824);structural constituent of cytoskeleton(GO:0016787) | intracellular(GO:0044464);microtubule(GO:0005622) | 1 |
| Q9UGM6 | Tryptophan--tRNA ligase, mitochondrial | NA | NA | cytoplasm(GO:0044464) | 1 |
| Q9UHT4 | Putative uncharacterized protein PR | #N/D | #N/D | #N/D | 1 |
| Q9UKN7 | Unconventional myosin-XV | G-protein modulator(PC00095);actin binding motor protein(PC00022);cell junction protein(PC00085) | enzyme regulator activity(GO:0003824);motor activity(GO:0030234);protein binding(GO:0016787);structural constituent of cytoskeleton(GO:0016462) | actin cytoskeleton(GO:0043226);intracellular(GO:0005856);plasma membrane(GO:0015629) | 1 |
| Q9ULL8 | Protein Shroom4 | ligand-gated ion channel(PC00227) | ligand-gated ion channel activity(GO:0005215);receptor activity(GO:0022857) | NA | 1 |
| Q9Y2H0 | Disks large-associated protein 4 | transmembrane receptor regulatory/adaptor protein(PC00226) | NA | NA | 1 |
| Q9Y493 | Zonadhesin | cell adhesion molecule(PC00069);extracellular matrix glycoprotein(PC00102) | NA | extracellular matrix(GO:0031012);extracellular region(GO:0005576) | 1 |
| Q9Y5T5 | Ubiquitin carboxyl-terminal hydrolase 16 | #N/D | #N/D | #N/D | 1 |
| Q9Y5Y6 | Suppressor of tumorigenicity 14 protein | annexin(PC00060);calmodulin(PC00050);peptide hormone(PC00131);protease inhibitor(PC00061);receptor(PC00207);serine protease(PC00179) | NA | NA | 1 |
| Q9Y6U3 | Adseverin | non-motor actin binding protein(PC00085) | actin binding(GO:0005488);structural constituent of cytoskeleton(GO:0005515) | actin cytoskeleton(GO:0043226);intracellular(GO:0005856) | 1 |