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. 2019 Oct 11;13:442. doi: 10.3389/fncel.2019.00442

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Copyright © 2019 Kong, Wang, Yang, Huang, Han, Yin, Liu, He and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPV1 activation enhances migration activity in cultured mice microglia. (A–F) Microglial cultures were scratched with tips, and immunocytochemistry was acquired with low magnification at 24 h with or without hyperthermia (43°C) and hyperthermia with CPZ (10 μM) in wild type microglia. (A) Control, (B) capsaicin (10 μM), (C) hyperthermia (4*30 min), (D) hyperthermia and capsazepine (CPZ, 10 μM), (E) hyperthermia and EGTA (2 mM), (F) hyperthermia and BAPTA-AM (10 μM). (G) Migration activity of microglia induced by capsaicin (10 μM) and hyperthermia (43°C) with or without Capsazepine (10 μM), EGTA (2 mM), BAPTA-AM (10 μM). Dotted lines show the initial location of the microglia. Notably, the cell number of the microglia invading the wound increases (Scale bar: 100 μm). Data are presented as mean ± SEM, n = 3 per groups, *p < 0.05, **p < 0.01, one-way ANOVA followed by Dunnett’s multiple comparison test with control.