Table 2.
GO functional enrichment analysis of common targets (top 10).
| Biological processes | GO ID | Related targets | FDR |
|---|---|---|---|
| Response to lipopolysaccharide | 0032496 | OPRM1, VCAM1, CASP3, CYP1A1, CASP9, PTGS2, JUN, CASP8, SLPI, CYP1A2, LBP, SELE | 9.99E-08 |
| Response to estradiol | 0032355 | CASP3, CASP9, PTGS2, SLC6A4, CASP8, ESR1, F7, CAT, CYP1A2, GSTP1 | 1.90E-07 |
| Response to drug | 0042493 | ICAM1, CASP3, IL6, CYP1A1, PTGS2, SLC6A2, JUN, BCL2, RELA, SLC6A4, PPARG, ADRA1A, CAT, STAT1 | 4.40E-07 |
| Positive regulation of nitric oxide biosynthetic process | 0045429 | OPRM1, AKT1, ICAM1, IL6, PTGS2, ESR1, INSR | 3.38E-05 |
| Steroid hormone mediated signaling pathway | 0043401 | PGR, NR1I3, NR1I2, RXRA, PPARG, NR3C2, ESR1 | 1.93E-04 |
| Aging | 0007568 | VCAM1, AKT1, IL6, CYP1A1, CASP9, RELA, JUN, ADRA1A, CAT | 5.98E-04 |
| Cellular response to lipopolysaccharide | 0071222 | ICAM1, IL6, RELA, MAPK8, LBP, NOS2, CD14, GSTP1 | 6.43E-04 |
| Xenobiotic metabolic process | 0006805 | CYP3A4, NR1I2, CYP1B1, PTGS1, CYP1A2, GSTP1, AHR | 4.00E+00 |
| Response to toxic substance | 0009636 | CYP1B1, BAX, BCL2, SLC6A4, PON1, GSTP1, AHR | 1.00E+00 |
| Positive regulation of transcription from RNA polymerase II promoter | 0045944 | AR, IL6, RXRA, RELA, PPARG, ESR1, STAT1, AHR, PGR, AKT1, ADRB2, NR1I3, NR1I2, NCOA2, JUN, PPP3CA, IKBKB | 3.00E+00 |