Figure 10.

iPS-NP survival and migration after transplantation at 17 weeks. Image of infiltrated by endogenous cells and cell elements positive for NF200 (A, C), GFAP (L and L¹–higher magnification of L) and CGRP (M and M¹–higher magnification of M). Image of differentiation transplanted cell into GFAP-positive astrocytes (L¹, the white dashed line on L¹ showing GFAP-negative human cells that have a neuron-like morphology), NF70- and NF200-positive neurons and mature neurons positive for calbindin (D-F and F¹–higher magnification of F), TH-5 (G-I and H¹, I¹), serotonin (J) and ChAT (K). Reproduced with permission from Romanyuk et al.¹¹ iPSC, induced pluripotent stem cell; NPs, neural precursors.