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. 2019 Jul 5;74(11):3135–3149. doi: 10.1093/jac/dkz256

Figure 2.

Figure 2.

Box plots of in vitro dolutegravir susceptibility results for 176 site-directed mutants and 105 clinical isolates containing R263K, G118R, N155H and/or Q148H/R/K. Purple plots indicate the fold reduction in susceptibility for viruses containing R263K with or without G118R, N155H and Q148H/R. Orange plots indicate the fold reduction in susceptibility for viruses containing G118R. Yellow plots indicate the fold reduction in susceptibility for viruses containing N155H with or without Q148H/R. Blue plots indicate the fold reduction in susceptibility for viruses containing Q148H/R/K. In addition to the four signature mutations, mutation patterns were characterized by the number of additional INSTI resistance mutations. The number of isolates with each pattern is shown in parentheses.