Table 8.
TNF-α and GSTs polymorphisms in response rate of MM patients.
| Variable | Response rate | |
|---|---|---|
| CR+VGPR+PR+SD | PD | |
| p-value | OR (95% CI) | |
| ISS | ||
| I+II | – | Reference |
| III | <0.001 | 5.44 (2.14–13.84) |
| Auto-HSCT | ||
| Yes | – | Reference |
| No | 0.015 | 3.36 (1.22–9.25) |
| TNFα−308G>A | ||
| GG | 1.0 | 1.02 (0.39–2.69) |
| GA+AA | – | Reference |
| TNFα−238G>A | ||
| GG | 0.45 | 0.69 (0.26–1.80) |
| GA+AA | – | Reference |
| GSTT1 | ||
| Present | 0.60 | 0.74 (0.24–2.24) |
| Null | – | Reference |
| GSTM1 | ||
| Present | 0.30 | 1.71 (0.61–4.80) |
| Null | – | Reference |
| TNFα−308 and−238 | ||
| GG+GG | 0.76 | 0.66 (0.19–2.32) |
| GA+AA+GA+AA | – | Reference |
| TNFα−308 and GSTT1 | ||
| GG+present | 0.41 | 0.30 (0.04–1.95) |
| GA+AA+null | – | Reference |
| TNFα−308 and GSTM1 | ||
| GG+present | 0.90 | 1.19 (0.27–5.16) |
| GA+AA+null | – | Reference |
| TNFα−238 and GSTT1 | ||
| GG+present | 0.93 | 0.56 (0.08–3.69) |
| GA+AA+null | – | Reference |
| TNFα−238 and GSTM1 | ||
| GG+present | 0.50 | 3.12 (0.36–27.0) |
| GA+AA+null | – | Reference |