Table 2.
Demographics and clinicopathologic demographics of patients with epithelioid MPM: comparison between patients treated with or without neoadjuvant chemotherapy (NAC).
| No NAC | NAC | |||
|---|---|---|---|---|
| N = 216 | N = 157 | N = 59 | P | |
| Age | 63 (56–70) | 58 (50–67) | 0.004 | |
| Sex | Female | 45 (29) | 18 (31) | 0.9 |
| Male | 112 (71) | 41 (69) | ||
| Smoking status (n = 167) | (–) | 28 (25) | 16 (28) | 0.7 |
| (+) | 82 (75) | 41 (72) | ||
| Asbestos (n = 154) | (–) | 37 (37) | 28 (53) | 0.060 |
| (+) | 64 (63) | 25 (47) | ||
| Procedure | EPP | 85 (54) | 38 (64) | 0.4 |
| PD | 63 (40) | 18 (31) | ||
| Other | 9 (6) | 3 (5) | ||
| R status (n = 205) | R1 | 126 (84) | 48 (87) | 0.7 |
| R2 | 24 (16) | 7 (13) | ||
| p-Stage | I | 6 (4) | 4 (7) | 0.5 |
| II | 40 (25) | 19 (32) | ||
| III | 93 (59) | 31 (53) | ||
| IV | 18 (11) | 5 (8) | ||
| T category (n = 215) | T1 | 10 (6) | 4 (7) | 1.0 |
| T2 | 69 (44) | 26 (44) | ||
| T3 | 65 (42) | 24 (41) | ||
| T4 | 12 (8) | 5 (8) | ||
| N category (n = 212) | N0 | 104 (67) | 46 (81) | 0.089 |
| N1 | 14 (9) | 1 (2) | ||
| N2 | 37 (24) | 10 (18) | ||
| Pleomorphic morphology | (–) | 133 (85) | 48 (81) | 0.5 |
| (+) | 24 (15) | 11 (19) | ||
| Lymphatic invasion (n = 215) | (–) | 78 (50) | 29 (49) | 1.0 |
| (+) | 78 (50) | 30 (51) | ||
| Vascular invasion (n = 215) | (–) | 118 (76) | 44 (75) | 0.9 |
| (+) | 38 (24) | 15 (25) | ||
| Ki-67 index (%) (n = 212) | 9.2 (3.8, 17.5) | 8.1 (3.4, 12.9) | 0.4 | |
| gC1qR expression | (–) | 2 (1) | 0 (0) | |
| (+) | 155 (99) | 59 (100) | ||
| gC1qR H-score (all) | 151 (80, 200) | 166 (99, 229) | 0.2 | |
| gC1qR H-score (no post-op chemo) (n = 88) | 149 (86, 202) | |||
| gC1qR H-score (post-op chemo) (n = 38) | 163 (80, 205) |
Data are number (%) or median (25 and 75 percentiles). MPM, malignant pleural mesothelioma; NAC, neoadjuvant chemotherapy; EPP, extrapleural pneumonectomy; PD, pleurectomy/decortication; gC1qR, globular heads of the C1q receptor. Bold value indicates significant p-value.