Table 5.
Univariable and multivariable analysis for any death in patients with epithelioid MPM in no NAC-cohort relative to gC1qR expression levels.
| gC1qR Low (n = 78) | gC1qR High (n = 79) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariable | Final multivariable model | Univariable | Final multivariable model | ||||||||||
| Hazard Ratio | 95%CI | P-value | Hazard Ratio | 95%CI | P-value | Hazard Ratio | 95%CI | P-value | Hazard Ratio | 95%CI | P-value | ||
| Age (per 1 year increase) | 1 | 0.97, 1.02 | 0.8 | 1.02 | 1.00, 1.04 | 0.12 | |||||||
| Male gender (vs. female) | 1.09 | 0.67, 1.78 | 0.7 | 1.65 | 0.95, 2.89 | 0.078 | |||||||
| Smoking (vs. non-smoking) | 1.38 | 0.70, 2.69 | 0.4 | 1.34 | 0.73, 2.46 | 0.3 | |||||||
| Asbestos (vs. non-asbestos) | 1.32 | 0.70, 2.50 | 0.4 | 1.11 | 0.61, 2.02 | 0.7 | |||||||
| Procedure (vs. EPP) | PD | 0.86 | 0.53, 1.38 | 0.5 | 0.85 | 0.52, 1.37 | 0.5 | ||||||
| Other | 1.81 | 0.70, 4.69 | 0.2 | 0.48 | 0.12, 1.97 | 0.3 | |||||||
| R2 (vs. R1) | 0.98 | 0.54, 1.77 | 0.9 | 1.27 | 0.58, 2.77 | 0.6 | |||||||
| Chemotherapy after surgery (vs. no chemotherapy) | 0.83 | 0.47, 1.46 | 0.5 | 0.5 | 0.28, 0.87 | 0.015 | 0.54 | 0.29, 0.99 | 0.047 | ||||
| P stage III/IV (vs. I/II) | 1.68 | 0.93, 3.02 | 0.083 | 1.41 | 0.76, 2.63 | 0.3 | 2.31 | 1.41, 3.79 | 0.001 | 2.99 | 1.66, 5.40 | 0.0003 | |
| T stage (vs. T1) | T2 | 1.14 | 0.27, 4.86 | 0.9 | 2.42 | 1.06, 5.50 | 0.036 | ||||||
| T3 | 1.09 | 0.26, 4.58 | 0.9 | 4.13 | 1.72, 9.88 | 0.001 | |||||||
| T4 | 1.13 | 0.23, 5.65 | 0.9 | 2.21 | 0.56, 8.70 | 0.3 | |||||||
| N stage (vs. N0) | N1 | 1.92 | 0.93, 3.98 | 0.079 | 3.51 | 1.36, 9.08 | 0.009 | ||||||
| N2 | 0.97 | 0.55, 1.73 | 0.9 | 1.73 | 1.00, 2.97 | 0.049 | |||||||
| Pleomorphic positive (vs. negative) | 2.86 | 1.43, 5.71 | 0.003 | 2.32 | 1.14, 4.74 | 0.02 | 1.48 | 0.78, 2.82 | 0.2 | ||||
| Lymphatic invasion positive (vs. negative) | 1.2 | 0.76, 1.91 | 0.4 | 1.9 | 1.19, 3.03 | 0.007 | |||||||
| Vascular invasion positive (vs. negative) | 1.52 | 0.87, 2.64 | 0.14 | 2.6 | 1.46, 4.64 | 0.001 | |||||||
| gC1qR H score | 1 | 1.00, 1.01 | 0.2 | 1 | 1.00, 1.01 | 0.6 | |||||||
| CD3 high (vs. low) | 1.84 | 1.10, 3.08 | 0.021 | 1.64 | 0.96, 2.78 | 0.068 | 0.77 | 0.48, 1.23 | 0.3 | ||||
| CD4 high (vs. low) | 1.4 | 0.87, 2.26 | 0.2 | 0.46 | 0.28, 0.73 | 0.001 | 0.35 | 0.19, 0.64 | 0.001 | ||||
| CD8 high (vs. low) | 1.01 | 0.64, 1.60 | 1 | 0.57 | 0.35, 0.92 | 0.021 | |||||||
| CD20 high (vs. low) | 0.93 | 0.58, 1.48 | 0.7 | 0.55 | 0.34, 0.88 | 0.013 | |||||||
| FoxP3 high (vs. low) | 0.93 | 0.58, 1.49 | 0.8 | 0.86 | 0.54, 1.37 | 0.5 | |||||||
| CD68 high (vs. low) | 1.94 | 1.19, 3.16 | 0.008 | 1.01 | 0.63, 1.60 | 1 | |||||||
| CD163 high (vs. low) | 1.46 | 0.91, 2.33 | 0.12 | 0.88 | 0.56, 1.40 | 0.6 | |||||||
| Ki67 high (vs. low) | 1.27 | 0.79, 2.02 | 0.3 | 4.8 | 2.66, 8.64 | <0.0001 | 7.13 | 3.36, 15.12 | <0.0001 | ||||
Data are number (%) or median (25 and 75 percentiles). MPM, malignant pleural mesothelioma; NAC, neoadjuvant chemotherapy; EPP, extrapleural pneumonectomy; PD, pleurectomy/decortication; gC1qR, globular heads of C1q; forkhead box P3. Bold values indicate significant p-value.