Table 1.

Some of targeted therapies in control and treatment of asthma

	Target	Effects	Th2high/low	References
Cell surface protein	Siglec-8	Apoptosis of eosinophils	High	294, 295
	CD300a	Activation of inhibitory receptor	High	296
	α4β1, α4β7	Increase blood eosinophils and inhibits their tissue accumulation	High	297
	CCR3	Block chemokine-induced eosinophils	High	298
	CXCR2	Reduce neutrophils	Low	16
	CD52	Deplete eosinophils	High	299
	EMR1	Deplete primate eosinophils	High	300
	CRTH2	Reduce tissue eosinophils	High	301
Transcription factor	GATA3	Reduce IL-5	High	302
Soluble mediator antagonist	Eotaxin-1	Inhibit eosinophil migration	High	303, 304
	IgE	Reduces allergic inflammation and exacerbations and airway obstruction	High	305, 306
	IL-4	Reduce allergic inflammation	High	307, 308
	IL-13	Reduce airway obstruction and cough	High	309, 310
	Interleukin-17RA	Reduce Th17 response	Low	311
	TSLP	Reduce eosinophils and allergic inflammation	High	312
	PGD2	improved Lung function	High	313, 314