Table 2.
The relationship of miRNA and inflammation response
| miRNA | Reaction and cell differentiate | Reference |
|---|---|---|
| miRNA-223 | Neutrophils mature and differentiate | 315 |
| miRNA-146, miRNA-146a | Airway epithelium, NF-kappa-B pathway | 316, 317 |
| miRNA-147 | TLR signaling pathway | 318 |
| miRNA-145 | Comparable to glucocorticoid treatment | 319 |
| miRNA-155 | TLR signaling pathway, regulation of allergic inflammation, macrophage inflammatory response, Th2 priming of dendritic cells | 320– 323 |
| miRNA-21 | TLR signaling pathway, NF-kB, IL-12p35 polarization | 324– 326 |
| miRNA-124 | M2 phenotype of monocytic cells | 327 |
| miRNA-148a, miR-148b, and miR-152 | HLA-G | 328, 329 |
| miRNA-126 | Th2 response, airway hyperresponse | 330 |
| let-7 | Il-13, regulation of allergic inflammation | 331– 333 |
| miRNA-221 | Mast cell activity regulates the production of cytokines | 334, 335 |
| miRNA-9 | Regulates steroid-resistant airway hyper-responsiveness | 336 |
| miRNA-672, miRNA-143 | Expression of metalloproteinase | 337 |
| miR-19a | Enhances proliferation of bronchial epithelial cells by targeting TGFbetaR2 gene | 338 |
| miRNA-203 | Negatively regulates c-Abl, ERK1/2 phosphorylation, and proliferation in smooth muscle cells | 339 |
| miRNA-133, miR-133a | Upregulation of Rhoa in bronchial smooth muscle cells | 340 |
| miR-192 | Decreased expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge | 341 |
| miR-212, miR-132, miR-182, miR-183 | upregulated Th17 cell differentiation | 342 |
| miR-106, miR-363 | downregulated Th17 cell differentiation | 342 |
| miR-18b, miR-106a, and miR-363-3p | expression of retinoid-related orphan receptor c (Rorc), Rora, IL-17a, and IL-17f and abolished secretion of Th17-mediated interleukin-17a (IL-17a) have declined | 342 |
| miR-18a | targeted Smad4, Hif1a, and Rora in the Th17 cell gene expression program | 343 |
| miRNA-34/449, let-7, miRNA-19, miRNA-21 and miRNA-455 | epithelial differentiation, mucus production, airway remodeling, and inflammation as well | 344 |
| miR-146a | modulate T-cell immunity as well as enhance class switch and secretion of IgE in B cells | 345 |
| miR-98 | suppress the expression of TSP1 (Thrombospondin 1) in the peripheral B cells | 330 |
| miR-221 | Upregulated expression promotes IgE-mediated activation of mast cell degranulation by PI3K/Akt/PLCgamma/Ca2+ signaling pathway | 346 |
| miR-223 | Downregulation promotes degranulation via the PI3K/Akt pathway by targeting IGF-1R in mast cells | 336 |
| miRNA-33b | Overexpression leads the mast cell degranulation was inhibited | 347 |
| miR-221 | Overexpression leads stimulated IL-4 secretion in mast cells through a pathway involving PTEN, p38, and NF-kappa-B | 348 |
| miR-223 | reduces IL-6 secretion in mast cells by inhibiting the IGF-1R/PI3K signaling pathway | 349 |
| miR-23b | induces tolerogenic DC and Treg through the inhibition of the Notch1 and NF-kB signaling pathways | 350 |
| miR-21 | regulates the Th1 and Th2 balance by targeting IL-12p35 expression and overexpression promotes differentiation of Th2 | 351, 352 |
| miR-139-5p, -15b-5p, 186-5p, 342-3p, 374a-5p, 409-3p, 454-3p, 660-5p, and -942-5p | lung function parameters (in males only) | 353– 355 |
| miR-1290, -142-3p, and 191-5p) with alone | lung function parameters (in females only) | |
| miR-296-5p, -548b-5p, -138-5p, -16-5p, -1227-3p, -30d-5p, -203a-3p and -128-3p | decreasing airway hyper-responsiveness | 356 |
| miR-143-3p | was shown to control TGF-b1-induced cell proliferation | 357, 358 |
| miR-181b-5p | was associated with airway eosinophilic inflammation by targeting osteopontin | 152, 359 |
| miR-223-3p, -142-3p and -629-3p | neutrophilic airway inflammation of the severe asthma | 360– 362 |